基于功效与药理作用川芎抗冠心病心绞痛的物质基础研究进展  

Progression of Material Basis Related to Angina Pectoris of Ligusticum chuanxiong Based on Efficacy and Pharmacology

作　　者：龚彦胜[1] 李晓宇[2] 孙蓉[1,3] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355 [3]山东中医药大学中医学博士后科研流动站,山东济南250355

出　　处：《中国药物警戒》2011年第11期675-678,共4页Chinese Journal of Pharmacovigilance

基　　金：重大新药创制新药研究开发关键技术:中药复方药理学研究及药效学评价关键技术(课题编号:2009ZX09502-015);山东省重大新药创制综合性大平台中药单元平台中药药理与毒理子平台建设(2009ZX09301-013);山东省中医药管理局项目(1999年第03号);山东省博士后创新项目:芍药苷对多梗塞性痴呆神经原损伤的体内保护作用(200801002)

摘　　要：目的总结川芎物质基础研究现状,明确川芎中与冠心病心绞痛相关的有效成分及其分子机制,为川芎在治疗冠心病心绞痛的应用提供文献依据和研究思路。方法对近二十年与川芎有关的文献进行整理、分析、归纳。结果川芎中与治疗冠心病心绞痛相关的成分主要有藁本内酯、川芎嗪、阿魏酸,对藁本内酯、川芎嗪、阿魏酸的药理作用研究较多,但对其作用机制及体内过程的研究尚不明确。结论川芎在冠心病心绞痛的治疗中疗效显著,对其抗冠心病心绞痛的物质基础、作用机制及体内过程等研究还处于初级阶段。Objective To summarizing the current states of material basis of Ligusticum chuanxiong, identify effective composition and its molecular mechanisms in Ligusticum chuanxiong related with angina pectoris, offer the accordance and research ideas for further research of Ligusticum chuanxiong. Methods The related references in recent 20 years about Ligusticum chuanxiong were analyzed, collated and summarized. Results The main compositions in Ligusticum chuanxiong related with angina pectoris are ligustilide, chuanxiongzine and feruhc acid. Research is almost on their pharmacological characteristics, but on molecular mechanisms is not deep enough. Conclusion Ligusticum chuanxiong has obvious therapeutic effect on angina pectoris. The effective composition and its molecular mechanisms related to angina pectoris are still at an initial stage.

关 键 词：川芎 冠心病心绞痛 物质基础 

分 类 号：R282[医药卫生—中药学]