2010年解放军第309医院地高辛血清浓度监测分析  

Monitoring of Serum Digoxin Concentration in No.309 Hospital of PLA During 2010

作　　者：程丽静[1] 熊晗晖[1] 冯端浩[1] 

机构地区：[1]解放军第309医院药剂科,北京100091

出　　处：《中国医院用药评价与分析》2011年第10期913-914,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解本院患者地高辛血清浓度(SDC)监测的结果,分析影响SDC的因素,为临床安全用药提供科学依据。方法:用荧光偏振免疫法测定SDC,结合临床资料进行统计和分析。结果:在266例次SDC监测患者的结果中,SDC<0.8 ng.mL-1的共90例,占33.83%。SDC在0.8～2.0 ng.mL-1的共133例,占50%。SDC>2.0 ng.mL-1的共43例,占16.17%。疗效明显的患者共监测180例次,占总例次的67.67%,疗效欠佳的患者共监测51例次,占19.17%,发生地高辛中毒的患者共监测35例次,占13.16%。结论:地高辛用药应结合血清浓度监测采用个体化用药方案,药师对监测结果应及时分析,并协助临床医师调整给药方案,使患者的治疗更加合理、有效。OBJECTIVE： To analyze the monitoring results on serum digoxin concentration（SDC） and analyze the factors affecting SDC so as to provide scientific references for clinical safe drug use.METHODS： The SDC was determined by fluorescence polarization immunization,and the results were subjected to statistical analysis by taking into consideration of clinical data.RESULTS： A total 266 cases received SDC monitoring,with SDC0.8 ng·mL-1 noted in 90（33.83%）,SDC=0.8-2.0 ng·mL-1 in 133（50.0%）,and2.0 ng·mL-1 in 43（16.17%）.180 cases（67.67%） had remarkable curative efficacy and 51 cases（19.17%） showed poor curative efficacy;35 cases（13.16%） had symptoms of poisoning by digoxin.CONCLUSION： The use of digoxin should be individualized based on monitoring on SDC;meanwhile pharmacists should analyze the monitoring results timely and cooperative well with clinician to adjust the dose regimen to achieve more rational and effective treatment.

关 键 词：地高辛 血清浓度监测 用药分析 

分 类 号：R972.1[医药卫生—药品]