血浆N末端B型利钠肽原对急性冠脉综合征患者住院病死率的预测价值  

Predictive Value of Amino-terminal pro B Type Natriuretic Peptide on Hospital Mortality in Patients With Acute Coronary Syndrome

作　　者：晏凯利[1] 刘汉华[1] 胡晓军[1] 孙跃玲[1] 陈苏[1] 郭丽芬[1] 

机构地区：[1]湖北省新华医院,武汉430015

出　　处：《内科急危重症杂志》2011年第5期285-286,289,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:评价血浆N末端B型利钠肽原(NT-proBNP)在预测急性冠脉综合征(ACS)患者住院病死率中的价值。方法:连续检测600例住院的ACS患者的血浆NT-proBNP水平。比较存活组和死亡组患者的血NT-proBNP水平。应用单因素和多元回归分析判断血浆NT-proBNP是否为ACS患者住院死亡的独立预测因素。结果:600例ACS患者中43例住院期间死亡,死亡组血浆NT-proBNP水平显著高于存活组[1512.5(1072.5～2321.0)pmol/L与672.3(305.9～1308.6)pmol/L,P<0.01]。回归分析表明,血浆NT-proBNP是ACS患者住院死亡的独立预测因素(P<0.01)。结论:入院时血浆NT-proBNP水平是ACS患者住院死亡的独立预测因素。Objective： To evaluate the value of amino-terminal pro B type natriuretic peptide （NT-proBNP） in predicting hospital mortality in patients with acute coronary syndrome （ACS）. Methods： Serum levels of NT-proBNP were determined in 600 patients with ACS within 24 hours after admission by the method of ELISA. The serum levels of NT-proBNP were compared between survivals and dying patients. Single factor and multiple logistic regress analyses were used to evaluate whether NT-proBNP was an independent predictor for in-hospital mortality. Results： Among 600 patients with ACS, serum level of NT-proBNP was significantly higher in 43 cases who died during hospitalization than those of survivals [1512.5（1072.5~2321.0） pmol/L vs 672.3 （305.9~1308.6） pmol/L, P0.01]. Regress analyses showed that NT-proBNP was an independent predictor for in-hospital mortality （P0.01）. Conclusion： Serum level of NT-proBNP on admission was an independent predictor for in-hospital mortality in patients with ACS.

关 键 词：N末端B型利钠肽原 急性冠脉综合征 住院病死率 

分 类 号：R541.4[医药卫生—心血管疾病]