肥胖患者载脂蛋白M水平及其与炎症因子的关系研究  

Apolipoprotein M Levels and its Relationship with Inflammatory Factors in Obesity

作　　者：李铁[1] 杨柳[2] 

机构地区：[1]湖南长沙市中心医院心血管内科,湖南长沙410000 [2]中南大学湘雅医院,湖南长沙410000

出　　处：《现代生物医学进展》2011年第21期4072-4074,共3页Progress in Modern Biomedicine

摘　　要：目的:观察肥胖患者载脂蛋白M水平并探讨其与炎症因子的关系。方法:58例体重正常者和36例肥胖患者常规测量体重、身高,计算体重指数,抽取空腹静脉血检测血脂、血浆载脂蛋白M(apoM)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)。结果:肥胖患者血浆apoM、高密度脂蛋白胆固醇(HDL-C)降低(P<0.05),IL-6、TNF-α、CRP水平升高(P<0.05),肥胖患者血浆apoM与HDL-C正相关,血浆apoM与IL-6、TNF-α、CRP水平负相关。结论:肥胖患者血浆apoM显著降低,apoM水平与CRP、TNF-α、IL-6水平密切相关,apoM可能受到这些炎症因子的调控。Objective： To observe the level ofapoM in obesity and explore the relationship between apoM and inflammatory factor. Methods： Obese patients （n=36） and healthy volunteers （n=58）were included, and their weight and height were measured. The Plasma apoM, fasting plasma lipids, Interleukin -6 （IL-6）, C-reactive protein （CRP）, tumor necrosis factor-α （TNF-α） were measured. Results： Obesity had lower plasma apoM, lower HDL-C （P〈0.05）. Conversely, 1L-6, TNF-α , CRP increased markedly in obesity group （P〈0.05）. In obesity, apoM was positively related to HDL-C level and negatively related to IL-6, TNF-α and CRP. Conclusions： Obese patients had lower apoM plasma. ApoM levels was closely related to CRP, TNF-α and IL-6 levels in obese patients, apoM may be regulated by these inflammatory factors.

关 键 词：肥胖 载脂蛋白M 炎症因子 

分 类 号：R589.2[医药卫生—内分泌]