掌跖脓疱病患者皮损糖皮质激素受体α和β表达的研究  

The Expression of GRα and GRβ in the Lesion of Pustulosis Palmaris et Plantaris

作　　者：杜明[1] 王丽梅[1] 王久江[1] 党瑞英[1] 王红斌[1] 

机构地区：[1]河北工程大学附属医院,河北邯郸056002

出　　处：《现代生物医学进展》2011年第21期4084-4086,共3页Progress in Modern Biomedicine

摘　　要：目的:为了解掌跖脓疱病患者皮损中GR表达情况,我们利用免疫组化方法检测患者皮损和正常皮肤标本中GR-α和GR-β的表达,从而探讨其表达在发病中的作用。方法:选择25例临床诊断为掌跖脓疱病患者皮损,26例外科手术切取的健康皮肤作为正常对照。用免疫组化SP法(链酶卵白素-过氧化物酶法)检测掌跖脓疱病患者皮损与正常对照组皮肤GR-α、GR-β的表达数量和强度。结果:两组GR-α表达无显著差异,患者组GR-β表达阳性率及强度明显高于对照组。结论:GR-β在掌跖脓疱病的发病过程中起重要作用。Objective： In order to understand the role and significance of the GR expressions in Pustulosis Palmaris et ttlantaris skin lesions, we investigated the expressions of GRα and GRβ with immunohistochemistry method on the healthy skin and patients. Method： The twenty-five resistant patients with Pustulosis Palmaris et Plantaris were enrolled into this study. The twenty-six healthy adult＇s skin was treated as controls, which were taken from skin of head by operation. Immunohistochemistry SP method （streptavidin-peroxidase technique） was used to detect the intensity and quantity of the GR expression in the patients group and normal control group. Results： The expression of GR-α showed no obvious difference between the two groups. Whereas the positive rate and intensity of GR-β was higher in patients group than control group. Conclusions： GR-β plays an important role in the pathologic progress ofpustulosis Palmaris et plantaris.

关 键 词：糖皮质激素受体Α 糖皮质激素受体Β 掌跖脓疱病 

分 类 号：R751[医药卫生—皮肤病学与性病学]