围术期应用肼苯哒嗪预防疝修补术后慢性疼痛的研究  

Perioperative Administration of Hydralazine Prevents Postoperative Chronic Pain After Herniorrhaphy

作　　者：张文宇[1] 蒋萌[2] 陈翎[2] 

机构地区：[1]湘潭市第一人民医院普外科,湖南湘潭411101 [2]中南大学湘雅医院普外科,湖南长沙410008

出　　处：《现代生物医学进展》2011年第21期4144-4146,4158,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨肼苯哒嗪对疝修补术后患者慢性疼痛发生率的影响。方法:选择单侧腹股沟疝患者48人,随机分为实验组(T组)和对照组(C组)各24例,在术前3天至术后4天共7天内接受药物或安慰剂治疗。其中T组每日两次,每次10mg肼苯哒嗪,C组同样方式给予安慰剂。测量患者术后4天内的平均动脉压(MAP)、心率(HR)、NRS急性疼痛评分以及术后3月、6月S-LANSS慢性疼痛评分。结果:T组患者术后MAP明显低于C组(P<0.05),HR两组相比无差异(P>0.05);两组患者术后急性疼痛程度相比无统计学差别(P>0.05);T组患者在术后3月和6月慢性疼痛发生率明显低于C组(P<0.05)。结论:常规剂量肼苯哒嗪可以用于术后患者,对疝修补术后急性疼痛无影响,但可以明显降低术后慢性疼痛的发生率。Objective： To explore the role of hydralazine in prevention of postoperative chronic pain. Methods： 48 patients with herniorrhaphy were randomly divided into Test group （T group, n=24） and Control group （C group, n=24）. The patients in T group were treated with 10 mg hydralazine BID, and the patients in C group was administered with placebo in the same manner. The MAP, HR, NRS score were measured during the first four days after operation, and S-LANSS scores were reported by every available patient at 3 and 6 months postoperatively. Results： The MAP level oft group patients was significantly lower than that of C group （P〈0.05）; HR in the two groups has no signicant difference（P〉0.05）.There was no significant differences of NRS scores in the two groups （P〉0.05）. The incidences of postoperative chronic pain was obviously lower in T group than those in C group （P〈0.05）. Conclusions： Hydralazine can obviously decrease the incidence of postoperative chronic pain rather than the acute pain in patients after hemiorrhaphy.

关 键 词：肼苯哒嗪 疝修补术 急性疼痛 术后慢性疼痛 

分 类 号：R656.2[医药卫生—外科学]