老年单纯收缩期高血压与靶器官损害的关系  

Relationship Between the Isolated Systolic Hypertension and Target Organ Damage in Aged Patients

作　　者：潘永瑜[1] 杨玲[1] 

机构地区：[1]上海交通大学医学院附属新华医院老年科,上海200092

出　　处：《中国血液流变学杂志》2011年第3期416-418,共3页Chinese Journal of Hemorheology

摘　　要：目的 探讨老年单纯收缩期高血压与靶器官损害的关系.方法 选择60岁以上原发性高血压患者120例,其中单纯收缩期高血压患者60例,非单纯收缩期高血压患者60例,2组患者均测定内生肌酐清除率（Ccr）,行超声心动图、颈动脉超声、颅脑CT和（或）MRI检查.比较Ccr、左室重量指数（LVMI ）、左室射血分数（LVEF ）、左室舒张早期充盈峰值流速（E峰）及舒张晚期左房收缩期充盈峰值流速（A峰）比值（E/A）、颈动脉中层厚度（IMT）,脑血管疾病的影像学证据.结果 2组患者左室肥厚、脑损害、肾功能损害及颈动脉斑块的差异均有统计学意义.结论 老年收缩期高血压与靶器官的损害密切相关,是比舒张期高血压更强的致靶器官损害因素.Objective To evaluate the relationship between the systolic hypertension and target organ damage in aged hypertensive patients. Methods 120 aged hypertensive patients were divided,60 with isolated systolic hypertension into group A and 60 with non-isolated systolic hypertension into group B.The tests of serum creatinine （Cr）,ech0cardiography（ECG）,carotid ultrasonography（CUS）,brain CT and（or） MRI were performed. Creatinine clearance rate（Ccr）,left ventricular mass index（LVMI）,left ventricular ejection fraction（LVEF）,the ratio of left ventricular early diastolic filling peak flow velocity（E peak） and left atrial systolic filling peak flow velocity in late diastolic phase（A peak）（E/A）,and carotid artery intima-media thickness（IMT） were compared.Results There were significant difference in incidence of hypertrophic left ventricular, cerebrum damage,renal damage,carotid intima-media thickness and atherosclerosis between isolated systolic hypertensive group and non-isolated systolic hypertensive group.Conclusion The isolated systolic hypertension damage to the target organ is stronger than the non-isolated systolic hypertension in aged oatients.

关 键 词：高血压 老年人 收缩压 舒张压 靶器官损害 

分 类 号：R544.1[医药卫生—心血管疾病]