苏州地区儿童呼吸道合胞病毒感染的流行病学研究  

Epidemiblogical Study of Respiratory Syncytial Virus Infection In Children of Suzhou Region

作　　者：顾凤珍[1] 周利兵[1] 张学兰[1] 杜晓晨[1] 谢敏慧[1] 

机构地区：[1]苏州大学附属儿童医院急诊科,江苏苏州215003

出　　处：《中国血液流变学杂志》2011年第3期474-477,484,共5页Chinese Journal of Hemorheology

摘　　要：目的 调查苏州地区儿童呼吸道合胞病毒（RSV）感染的流行现状及其影响因素,为RSV感染的防治提供依据.方法 收集苏州大学附属儿童医院2008年5月～2011 年4月三年间因呼吸道感染住院的患儿痰标本18,170例,采用直接免疫荧光法检测RSV抗原.结果 18,170例呼吸道感染患儿中,RSV阳性者2,773例,阳性检出率15.26%,82.87%的RSV感染发生在12月以下患儿;男女比例1.97：1（P＜0.001）,发病高峰集中在每年的12月至次年的3月;12月以内母乳喂养儿较非母乳喂养儿RSV阳性检出率低,年龄小于6月或在流行季节出生、被动吸烟、母亲吸烟、兄妹数量等均可增加RSV的感染率.结论 苏州地区儿童RSV感染的流行状况与国内和国外温带城市情况基本一致,冬春季为流行高峰,0～12月龄组的患儿RSV感染所占比例最大.母乳喂养具有保护作用,男性、被动吸烟、母亲吸烟、多兄弟姐妹、年龄小于6月或在流行季节出生等因素均增加患儿RSV感染风险.Objective To investigate the epidemiology and influential factors of respiratory syncytial virus infection in children of Suzhou region,thus to guideline the prevention and treatment of RSV infection. Methods To collect 18,170 sputum samples of children who were hospitalized to Children＇s Hospital Affiliated to Soochow University due to respiratory infection between May 2008 to April 2011 and detect RSV antigen using direct immunofluorescence. Results 2,773 children were found RSV positive,and the positive detection rate was 15.26%,82.87% of RSV infection occurred below 12-month age;Male female ratio was 1.97：1（P 〈 0.001）,the morbidity peak was from December to following March.The RSV positive detection rate was lower in breast feeding infants than non-breast feeding infants below 12 months. 〈 6-month age being born in epidemic season,passive smoking,maternal smoking,brother-sister number, etc,can increase the infection rate of RSV. Conclusion The epidemic status quo of RSV infection in children of Suzhou region was consistent with other temperate zone cities home and abroad.The epidemic peak was in winter and spring.0 - 12 months age group constituted the most in RSV infection.Breast feeding had protective effect.Factors,such as male gender, passive smoking,maternal smoking,multiple brothers or sisters,age below 6 months,being born in epidemic season,can all increase the RSV infection risk.

关 键 词：呼吸道合胞病毒 儿童 流行病学 

分 类 号：R725.6[医药卫生—儿科]