Convenient Synthesis of 3,5-Biscarbamoyl-pyridine Derivatives  

作　　者：汪霞云 朱逸雯 张敏 陆东亮 钱群 陈雅丽 曹卫国 宋力平 邓红梅 

机构地区：[1]Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China [2]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [3]Instrumental Analysis and Research Center, Shanghai University, Shanghai 200444, China

出　　处：《Chinese Journal of Chemistry》2011年第10期2119-2123,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20872086, 21072128）, the Leading Academic Discipline Project of Shanghai Municipal Education Commission （No. J50102）, the Foundation of Education Commission of Shanghai Municipality （No. 08zz44）, and the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry.

摘　　要：An efficient and convenient method for synthesis of 3,5-bis-carbamoyl-2,6-dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5-bis（3＇,5＇-dimethy1-1＇-pyrazolyl-carbony1）-2,6- dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.An efficient and convenient method for synthesis of 3,5-bis-carbamoyl-2,6-dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5-bis（3＇,5＇-dimethy1-1＇-pyrazolyl-carbony1）-2,6- dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.

关 键 词：HETEROCYCLES AMIDE aromatic amine SYNTHESIS 

分 类 号：O626.32[理学—有机化学] TQ655[理学—化学]