β半乳糖凝集素-3在胚泡植入早期小鼠子宫内膜中的表达  

Expression of Galectin-3 in the early mouse embryo implantation in endometrial

作　　者：黄丽[1,2] 陈晓蓉[1] 张荣宜[1] 

机构地区：[1]安徽医科大学组织胚胎学教研室,合肥230032 [2]安徽医学高等专科学校临床医学系,合肥230601

出　　处：《安徽医科大学学报》2011年第11期1121-1124,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学基金重点项目(编号:KJ2007A034)

摘　　要：目的探讨β半乳糖凝集素-3(Galectin-3)在植入早期小鼠子宫内膜中的表达分布状况及其意义。方法应用免疫组化SP法检测妊娠1～5 d小鼠子宫内膜Galectin-3的表达情况,并以动情期非妊娠小鼠子宫做对照。结果小鼠子宫内膜的所有组织中均有Galectin-3表达,主要表达于腺上皮、腔上皮和基质细胞中。随着小鼠妊娠天数的增加,Ga-lectin-3的表达也逐渐增高,在植入窗口期(妊娠4～5 d)达高峰。结论 Galectin-3在妊娠1～5 d小鼠子宫内膜持续表达,提示在小鼠胚泡植入早期,Galectin-3参与了胚泡的植入过程,在胚泡和子宫内膜的识别过程中发挥重要作用。Objective To study the expression and distribution of Galectin-3 and its significance in the mouse endometrium during early implantation.Methods Immunohistochemical SP staining method was used to detect the expression of Galectin-3 in mouse endometrium on day 1～5 of pregnancy and the un-pregnant mouse endometrium（estrous stage） were selected as controls.Results Galectin-3 was detected throughout mouse endometrial tissue,especially in glandular epithelial,luminal epithelial and stromal cells.With the increase in the number of days of pregnancy in mice,Galectin-3 expression also gradually increased and reached a peak in the implantation window period（pregnancy 4～5 d）.Conclusion Galectin-3 is expressed continuously in mouse endometrium on day 1～5 of pregnancy.It suggests that Galectin-3 may take part in the process of blastocyst implantation in early blastocyst implantation in mice.Galectin-3 plays an important role in the identification process of the blastocyst and the endometrium.

关 键 词：胚泡植入 子宫内膜 小鼠 β半乳糖凝集素-3 

分 类 号：R321.3[医药卫生—人体解剖和组织胚胎学] R322.65[医药卫生—基础医学]