骨质疏松性骨折椎体成形术后的疗效影响因素  

Influencing factors of long-mid term efficacy following percutaneous vertebroplasty in patients with osteoporosis

作　　者：刘文贵[1] 何仕诚[1] 邓钢[1] 郭金和[1] 方文[1] 朱光宇[1] 滕皋军[1] 

机构地区：[1]东南大学附属中大医院放射科,南京210009

出　　处：《中华医学杂志》2011年第39期2772-2775,共4页National Medical Journal of China

摘　　要：目的探讨经皮椎体成形术（PVP）治疗骨质疏松性椎体压缩骨折（OVCF）患者的中一远期疗效及影响疗效的因素。方法2005年3月至2009年12月间以相同的研究标准对131例OVCF患者进行前瞻性研究，以VisualAnaogScale（VAS）、Roland—MorrisDisabilityQuestionnaire（RDQ）及患者的活动水平数据评价治疗效果并分析影响中一远期疗效的因素。结果患者术后的VAS、RDQ评分或活动水平均得到明显改善（均P〈0．05）；单、多因素分析显示年龄、单次骨折椎体数、术后活动水平及出现新发骨折均与中一远期疗效差异有统计学意义（P=0．043、0．007、0．001和0．034）。结论PVP可快速缓解OVCF患者的疼痛并改善其生活质量，中一远期疗效主要与其年龄及基础病变程度相关。Objective To determine the therapeutic efficacy and the influencing factors for the long/middle-term outcomes of pereutaneous vertebropiasty （PVP） in the treatment of painful osteoporotie vertebral compression fractures （OVCFs）. Methods This prospective study recruited a total of 131 consecutive OVCF patients treated with PVP at a single institution from March 2005 to December 2009. There were 106 females and 25 males. Pre- and postoperative evaluations included a visual analog scale （VAS） for pain, the Roland-Morris disability questionnaire （RDQ） scores and patient activity levels. Various factors probably correlated with long-mid term efficacy were also analyzed. Results Both VAS and RDQ scores decreased significantly （ P 〈 O. 05 ）. And the activity levels showed significant post-therapeutic improvement （P 〈 0. 01 ）; Univariate and multivariate analysis showed that the influencing factors for the long/middle- term efficacy were age, number of OVCF （s） per time, activity level after discharge and newly occurring OVCF （Z= -2.03, -2.68, 5.38 and -1. 73; P=0.043, 0.007, 0.001 andO. 034 respectively）. Conclusion PVP is an efficient pain-relieving procedure. The long/middle-term efficacy after PVP is mostly correlated with both the patient age and the natural course of underlying conditions.

关 键 词：骨质疏松 骨折 椎体成形术 

分 类 号：R687.3[医药卫生—骨科学]