影响动脉血栓形成因素的超声研究  

Influencing Factors of Artery thrombus by Ultrasound

作　　者：关丽娜[1] 穆玉明[1] 王春梅[1] 郭朝峰[1] 姜涛[2] 

机构地区：[1]新疆医科大学第一附属医院超声医学中心心脏超声诊断科,乌鲁木齐市830011 [2]新疆医科大学第一附属医院实验动物中心,乌鲁木齐市830011

出　　处：《中国超声医学杂志》2011年第10期873-877,共5页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金资助(No.30860267)

摘　　要：目的应用超声技术研究不同浓度FeCl_3联合不同干预方法制备兔股动脉内混合性血栓的影响因素,达到为溶栓研究提供稳定、方便的血栓模型。方法 30只新西兰大白兔总60条股动脉,分别根据FeCl_3浓度、外敷法和内注射法和是否联合股动脉远端夹闭将动物分为3组,应用超声监测血栓形成情况,然后对血管行病理检查。结果外敷10%FeCl_3联合股动脉夹闭形成闭塞性血栓优于其他浓度(P<0.001),FeCl_3外敷法形成血栓优于内注射法(P<0.001),10%FeCl_3外敷法联合远端夹闭形成血栓优于无夹闭的条件(P<0.001)。结论股动脉10%FeCl_3外敷联合夹闭是形成血小板为主的混合性血栓的最优方法。Objective To analyze the influence factor of different doses of ferric chloride combined with different intervention methods in inducing occlusive and platelet-rich thrombus thus affording a stable and convenient animal model for thrombolysis research. Methods A total of 30 rabbits and 60 arteries were divided into three groups by the following factors： doses of ferric chloride, methods of out-applying,inter-injection, to observe thrombus formation, monitoring thrombosis by ultrasound and pathological examination. Results Occlusive thrombus formed by external applying 10% ferric chloride outperformed other doses （P〈0. 001）, occlusive thrombus formed by external applying 10% ferric chloride outperformed inter-injection （P〈0. 001）, and occlusive thrombus formed by external applying 10% ferric chloride combined with the completely occlusive distal of femoral artery outperformed that without occlu- sion （P〈0. 001）. Conclusions Occlusive thrombus formed by external applying 10% ferric chloride combined with femoral artery occlusion is the key factor in successfully inducing the occlusive and platelet rich thrombus formation.

关 键 词：混合性血栓 FeCl3外敷法 股动脉夹闭 超声 

分 类 号：R445.1[医药卫生—影像医学与核医学]