3.0T多体素1H-MRS在颅内病变诊断中的应用价值  

3.0T Multi-Voxel 1H-MR Spectroscopy In Application Value Of Intracranial Disease Diagnosis

作　　者：林祺[1] 陈金银[1] 许凯华[1] 林荣良[1] 

机构地区：[1]福建医科大学附属龙岩第一医院放射科,福建龙岩364000

出　　处：《中国CT和MRI杂志》2011年第5期36-38,共3页Chinese Journal of CT and MRI

基　　金：福建省医学创新课题(编号:2011-CXB-28)

摘　　要：目的探讨3.0T多体素氢质子磁共振波谱(1H-MRS)在颅内病变诊断中的应用价值。方法选取40例经手术病理证实或临床确认颅内疾病患者和10例健康志愿者。应用双梯度16通道3.0T磁共振成像系统进行检查。分别测定病变区、病变周围及健侧相应区域的胆碱(Cho)/肌酸(Cr),乙酰天门冬氨酸(NAA)/Cr,Cho/NAA值,结果—以x±s表示,界值取P<0.05。结果胶质瘤组与转移瘤组Cho/Cr,NAA/Cr,Cho/NAA的比值差异有统计学意义(P<0.05),胶质瘤组与亚急性脑梗死组Cho/NAA的比值差异有显著统计学意义(P<0.01),胶质瘤组与健康自愿者组Cho/NAA的比值差异有显著统计学意义(P<0.01),脑膜瘤组与亚急性脑梗死组Cho/NAA的比值差异有统计学意义(P<0.05),脑膜瘤组与健康自愿者组Cho/NAA的比值差异有统计学意义(P<0.05),转移瘤组与亚急性脑梗死组Cho/Cr,NAA/Cr的比值差异有统计学意义(P<0.05),转移瘤组与健康自愿者组Cho/Cr,NAA/Cr的比值差异有统计学意义(P<0.05)。结论 3.0T多体素1H-MRS在颅内病变定性诊断和鉴别诊断中具有重要价值。Objective To reveal the value of 3.0T multi-voxe 1H-MR Spectroscopy（1H-MRS） in the application of intracranial disease.Methods 40 cases confirmed by histopathologic findings or clinical follow-up and 10 normal volunteers were collected.Using a 3.0T Dual gradient 16 channels MR system,all the cases performed.The ratios of Cho/Cr,NAA/Cr,Cho/NAA were measured in the disease,circum of diseases and contralateral parenchyma respectively.The results was expressed by x,and value was set as P0.05.Results There were significant differences（P0.05） in the ratios of Cho/Cr,NAA/Cr,Cho/NAA of gliomas group compared with metastatic tumors group.There were remarkable significant differences（P0.01） in the ratios of Cho/NAA of gliomas group compared with subacute cerebral infarction group,There were remarkable significant differences（P0.01） in the ratios of Cho/NAA of gliomas group compared with normal volunteers group.There were significant differences（P0.05） in the ratios of Cho/NAA of meningioma groug compared with subacute cerebral infarction group.There were significant differences（P0.05） in the ratios of Cho/NAA of meningioma groug compared with normal volunteers group.There were significant differences（P0.05） in the ratios of Cho/Cr,NAA/Cr of metastatic tumors group compared with subacute cerebral infarction group.There were significant differences（P0.05） in the ratios of Cho/Cr,NAA/Cr of metastatic tumors group compared with normal volunteers group.Conclusion 3.0T multi-voxe 1H-MRS is of great value for the intracranial disease in qualitative diagnosis and differential diagnosis.

关 键 词：质子磁共振波谱 颅内疾病 应用价值 

分 类 号：R445.2[医药卫生—影像医学与核医学] R65[医药卫生—诊断学]