中分化松果体细胞瘤  

Pineal parenchymal tumors of intermediate differentiation

作　　者：张明山[1] 张宏伟[1] 张俊平[2] 夏雷[1] 曲延明[1] 王浩然[1] 于春江[1] 

机构地区：[1]首都医科大学第十一临床医学院,北京三博脑科医院神经外科,北京100093 [2]首都医科大学第十一临床医学院,北京三博脑科医院神经肿瘤化疗科,北京100093

出　　处：《首都医科大学学报》2011年第5期692-696,共5页Journal of Capital Medical University

摘　　要：目的探讨中分化松果体细胞瘤的临床特点及治疗方法。方法回顾性分析北京三博脑科医院神经外科收治的6例中分化松果体细胞瘤病人的临床表现、影像学特点、病理学特点和治疗方法。对1例患者行开颅活检术,5例患者行经胼胝体穹窿间入路切除肿瘤。5例患者进行r-刀治疗,4例患者放疗,4例患者化疗。结果全脑全脊髓播散转移患者4例,肿瘤全切1例,近全切除3例,大部切除1例,部分切除活检1例,r-刀有效2例,放疗有效2例,化疗有效3例。结论中分化松果体细胞瘤易发生全脑全脊髓播散,治疗仍然需要多手段进行干预,肿瘤要争取全切除,术后应辅以放疗及化疗。Objective To investigate the clinical characteristics and treatments of pineal parenchymal tumors of intermediate differentiation（PPTID）.Methods Data of 6 cases of PPTID admitted to the Department of Neurosurgery from June 2009 to July 2010 were analyzed.The statistical data include clinical features,radiological,pathological characteristics and treatments.Among the six cases,one case underwent transcranial biopsy,five cases underwent transfrontal-interforniceal approach for tumor resection,five patients received gamma-knife,four patients received radiotherapy and four patients received chemotherapy.Results The whole neuraxis disseminating of the tumor were found in four cases.Among the six cases,one tumor was totally removed;three with subtotal removal and one with partially removal,one case performed biopsy.The symptoms were improved in two patients after radiation,two patients after gamma-knife,and three patients after chemotherapy.Conclusion PPTIDs are liable to disseminate through the central nervous system.Multiple treatments are needed for PPTIDs,the tumors should be resected totally as far as possible and the postoperative radiotherapy or chemotherapy are necessary for this entity.

关 键 词：中分化松果体细胞瘤 全脑全脊髓转移 手术 化疗 放疗 

分 类 号：R651.12[医药卫生—外科学]