Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia  

作　　者：Haiming Qin Fulin Song Hongguang Han Hong Ou Xingwen Zhai Bin Qin Song You 

机构地区：[1]School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China [2]Department of Pathology, General Hospital of Shenyang Mifitary Area Command of Chinese PLA, Shenyang 110016, Liaoning Province,China

出　　处：《Neural Regeneration Research》2011年第27期2105-2111,共7页中国神经再生研究（英文版）

基　　金：a Research Subject of General Hospital of Shenyang Military Area Command of Chinese PLA

摘　　要：The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia （at 8 hours after pMCAO）, inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia （at 8 hours after pMCAO）, inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.

关 键 词：bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration 

分 类 号：Q42[生物学—神经生物学] S851.43[生物学—生理学]