Shallow needling on Neiguan and Gongsun acupoints in rats with brain ischemia Changes in apoptosis regulating genes and vasoactive substances  

作　　者：Yushan Fan Caijiao Zhao Wei Huang Yan Luo Yong Pang Huangsha Fan Xingui Wu Jinsheng Wang 

机构地区：[1]Institute of Acupuncture ＆ Moxibustion, Guangxi Traditional Chinese Medical University, Nanning 530001, Guangxi Zhuang AutonomousRegion, China [2]Department of Acupuncture and Moxibustion, First Hospital Affiliated Hospital to Guangxi Traditional Chinese Medical University, Nanning 530023, Guangxi Zhuang Autonomous Region, China [3]First Affiliated Hospital to Guangxi Traditional Chinese Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China [4]Department of Pathology, Guangxi Traditional Chinese Medical University, Nanning 530001, Guangxi Zhuang Autonomous Region, China

出　　处：《Neural Regeneration Research》2011年第27期2118-2123,共6页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No. 3076031918

摘　　要：For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present study established middle cerebral artery occlusion models in rats using the thrombosis method. Shallow needling and conventional needling at the bilateral Neiguan （PC 6） and Gongsun （SP 4） acupoints improved neurological function of middle cerebral artery occlusion rats, increased the expression of the anti-apoptotic Bcl-2, inhibited the expression of the pro-apoptotic Bax, and reduced the expression of the vasoactive substances nitric oxide synthase and endothelin-1. However, these changes were more pronounced in the shallow needling group, indicating that shallow needling is more effective in inhibiting brain ischemic injury.For the treatment of brain ischemia using acupuncture, the needle is predominantly inserted into muscular layers and deep tissue. However, few studies have investigated the outcomes of shallow needling. The present study established middle cerebral artery occlusion models in rats using the thrombosis method. Shallow needling and conventional needling at the bilateral Neiguan （PC 6） and Gongsun （SP 4） acupoints improved neurological function of middle cerebral artery occlusion rats, increased the expression of the anti-apoptotic Bcl-2, inhibited the expression of the pro-apoptotic Bax, and reduced the expression of the vasoactive substances nitric oxide synthase and endothelin-1. However, these changes were more pronounced in the shallow needling group, indicating that shallow needling is more effective in inhibiting brain ischemic injury.

关 键 词：shallow needling cerebral infarction Bcl-2 Bax nitric oxide synthase endothelin-1 neural regeneration 

分 类 号：Q463[生物学—生理学] Q255