维生素E对孕鼠及胎鼠脑组织受手机辐射影响的保护作用  

Protective effects of vitamin E against electromagnetic radiation from cell phones in pregnant and fetal rats' brain tissues

作　　者：张静[1] 张裕华[2] 姜荣平[3] 廉志顺[1] 王慧[1] 罗芮[1] 郭冬梅[1] 崔晞[1] 

机构地区：[1]山东大学公共卫生学院卫生检验研究所,济南250012 [2]山东大学附属千佛山医院放射科,济南250014 [3]山东省化工研究院,济南250014

出　　处：《山东大学学报（医学版）》2011年第9期33-36,共4页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金资助课题(Y2007C086)

摘　　要：目的研究妊娠期补充维生素E对母鼠及胎鼠脑组织受手机辐射影响的保护作用。方法 40只受孕大鼠随机分为5组,自妊娠第1天起,维生素E低、中、高剂量组分别按5 mg/kg、15 mg/kg、30 mg/kg的剂量补充,阴性对照组和阳性对照组灌服脱维生素E的花生油,同时给予1 h/次、3次/d的手机辐射,连续辐射21 d,分娩后测定母鼠及胎鼠脑组织总抗氧化能力(T-AOC)和ATP酶(Na+-K+-ATP酶和Ca+-Mg+-ATP酶)的活力变化。结果阳性对照组T-AOC、Na+-K+-ATP酶、Ca+-Mg+-ATP酶活性均较阴性对照组下降(P<0.05)。与阳性对照组比较,维生素E各剂量组T-AOC含量升高,其中,母鼠维生素E中、高剂量组较阳性对照组升高,胎鼠维生素E低、中、高剂量组均高于阳性对照组(P<0.05)。母鼠维生素E各剂量组Na+-K+-ATP酶和Ca+-Mg+-ATP酶活力均高于阳性对照组,胎鼠维生素E中、高剂量组ATP酶活力较阳性对照组升高(P<0.05)。结论维生素E对受手机辐射影响的母鼠及胎鼠的抗氧化能力和能量代谢有一定的保护作用。Objective To investigate protective effects of maternal vitamin E supplement against electromagnetic radiation from cell phones in pregnant and fetal rats＇ brain tissues.Methods 40 pregnant rats were randomly divided into five groups.Low,middle and high dosages of vitamin E groups were supplemented with 5 mg/kg,15 mg/kg,and 30 mg/kg of vitamin E,respectively.The negative control group and the positive control group were given peanut oil which had vitamin E removed.All groups were exposed to a certain intensity of cell phone radiation for 1 hour each time,3 times per day for 21 days from the first day of pregnancy.Total anti-oxidant capacity（T-AOC） and ATP enzyme（Na＋-K＋-ATP enzyme and Ca＋-Mg＋-ATP enzyme） activities in pregnant and fetal rats＇ brain tissues were determined after delivery.Results T-AOC,Na＋-K＋-ATP enzyme activity,and Ca＋-Mg＋-ATP enzyme activity were all significantly lower in the positive control group than in the negative control group（P0.05）.Compared with the positive control group,T-AOC of pregnant mice was significantly higher in middle and high dosages of vitamin E groups,and T-AOC of fetal mice was significantly higher in all three different dosages of vitamin E groups（P0.05）.ATP enzyme activity in pregnant mice was significantly increased in the three dosages of vitamin E groups compared with the positive control group（P0.05）,and that in fetal mice was higher in middle and high dosages of vitamin E groups than in the positive control group（P0.05）.Conclusion Vitamin E has a protective effect against damage to antioxidant capacity and energy metabolism induced by cell phone electromagnetic radiation in pregnant mice and fetal mice.

关 键 词：维生素E 手机辐射 总抗氧化能力 ATP酶 大鼠 Wistar 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]