高强度聚焦超声联合放疗治疗晚期肝癌41例  

Efficacy of High Intensity Focused Ultrasound Combined with Radiotherapy on Primary Hepatocellular Carcinoma

作　　者：王继营[1] 李峻[1] 仲荣达[1] 田丹[1] 李崇阳[1] 田雪峰[1] 

机构地区：[1]云南省第二人民医院肿瘤科,昆明市650021

出　　处：《中华全科医学》2011年第11期1702-1703,共2页Chinese Journal of General Practice

摘　　要：目的观察高强度聚焦超声(HIFU)联合三维适形放疗(3DCRT)治疗晚期原发性肝癌近期疗效。方法对41例晚期肝癌给予3DCRT治疗,单次剂量3 Gy/次,3～4次/周,总剂量39～60 Gy,中位总剂量达52 Gy,4～5周完成。同步给予HIFU,平均接受治疗6次(4～10次)。结果 41例患者均可评价疗效,肿瘤体积变化CR 2例、PR 27例、NC 9例、PD 3例。总有效率MR 70.73%(CR+PR)。1年、2年生存率分别为75.60%(31/41)、53.66%(22/41),中位TTP14.6个月。临床受益指数92.68%(38/41)。结论 HIFU+3DCRT方案同步治疗晚期原发性肝癌可适当延长生存期,提高生活质量,无明显的不良反应。Objective To observe the short term efficacy of high intensity focused ultrasound（HIFU） combined with three dimensional conformal radiotherapy（3D-CRT） on primary hepatocellular carcinoma（PLC）.Methods HIFU and 3D-CRT were performed in 41 patients with PHC.In 3D-CRT treatment,the patients were irradiated with a fraction of 3 Gy,and 3 to 4 fractions（dose of 39-60 Gy） a week,and total to 4 to 5 weeks.While the HIFU treatment was 4 to 10（mean 6） fractions.Results Forty-one patients were evaluable for response,in which 2 case complete response（CR） in the volume of tumor,27 case partial response（PR）,9 case no change（NC） and 3 case progressive disease（PD）,namely the MR was 70.73%.The 1-and 2-year survival were 75.60%,53.66% respectively and foe all patients the mediam survival period was 14.6 months.The clinical beneficial indice was 92.68%.Conclusion HIFU in combinatiom with 3D-CRT is a safe,minor-invasive treatment.It was proved to be effective in alleviating the sufferings,improving clinical beneficial indices and extending life circle in PLC.

关 键 词：原发性肝癌 超声治疗/高强度聚焦超声热疗 放射治疗/三维适形放疗 

分 类 号：R735.7[医药卫生—肿瘤] R730.54[医药卫生—临床医学]