化学药及中药缓释制剂的药动学研究进展  

Progress of Pharmacokinetic Study on Sustained-Release Preparation of Chemical Drugs and Traditional Chinese Medicine

作　　者：张志鹏[1] 刘艳[1] 吴燕红[1] 朱盛山[1] 

机构地区：[1]广东药学院中药开发研究所,广东广州510006

出　　处：《时珍国医国药》2011年第1期223-226,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30973954);国家科技部"十一五"支撑项目(No.2006BAI09B08-2);广州重大科技专项计划子项目(No.2008A1-E4101-3);广东省中医药管理局项目(No.2008171)

摘　　要：目的综述化学药、中药缓释制剂的药动学研究进展,为开展中药缓释制剂设计提供参考。方法综述液相色谱法、离子选择电极法、气相色谱法、质谱联用技术以及串联质谱法等在化学药缓释制剂药动学中的应用;中药单体、中药有效部位、中药复方缓释制剂的药动学研究进展。结果化学药检测限越来越低;中药缓释制剂常应用血药浓度法和药理效应法进行药动学的研究。结论现代分析技术可以更加准确、稳定地测定化学药的血药浓度;血药浓度法和药理效应法对测定中药缓释制剂药动学具有针对性。化学药缓释制剂药动学文献资料可指导中药缓释制剂药动学研究。Objective To review the latest progress of pharmacokinetic study on sustained-release preparation of chemical drugs and traditional Chinese medicine（TCM）,in order to provide a reference for design of sustained-release preparation of TCM.Methods The paper reviewed the use of HPLC,Ion-selective electrode,GC,LC/MS,LC/MS/MS in the pharmacokinetic study on sustained-release preparation of chemical drugs and the pharmacokinetic studies in effective parts,single drug,and compound drugs of TCM.Results Chemical drugs get lower and lower limits of detection;blood concentrations and pharmacological effects of sustained-release preparation of TCM in the pharmacokinetics study.Conclusion Modern analytical techniques can be more accurate and stable in the measurement of blood concentration of chemical drugs;Plasma concentration method and pharmacological effects of sustained-release preparation can be adopted to determine the pharmacokinetics of TCM;Chemical drugs pharmacokinetics of sustained-release formulations literature can guide pharmacokinetics of sustained-release preparations of Chinese medicine research.

关 键 词：中药 缓释制剂 药动学 

分 类 号：R283[医药卫生—中药学]