一枝蒿有效部位对小鼠免疫功能的影响  

Effects of Active Component of Artemsia rupestris L. on Immune Function in Mice

作　　者：孟繁龙[1] 李治建 斯拉甫.艾白 阿布都吉力力 范晓红[1] 周露[1] 

机构地区：[1]新疆石河子大学药学院,新疆石河子832000 [2]新疆维吾尔自治区维吾尔医药研究所,新疆乌鲁木齐830049 [3]新疆维吾尔自治区维吾尔医医院,新疆乌鲁木齐830049

出　　处：《时珍国医国药》2011年第3期537-539,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30660238)

摘　　要：目的研究一枝蒿有效部位(AR)对小鼠免疫系统的影响。方法采用二硝基氯苯(DNCB)致小鼠迟发型超敏反应模型、鸡红细胞诱导小鼠血清溶血素生成模型,观察AR对小鼠细胞免疫与体液免疫的影响;用体外实验方法测定AR对小鼠T、B淋巴细胞增殖的影响及小鼠腹腔巨噬细胞吞噬功能影响。结果 AR可明显增加小鼠脾指数和胸腺指数、对鸡红细胞诱导的小鼠血清溶血素生成具有促进作用,可促进小鼠T、B淋巴细胞的增殖及增强小鼠吞噬细胞的吞噬功能。结论 AR对非特异免疫、细胞免疫和体液免疫功能均有明显的促进作用。Objective To study the effects of active component of Artemsia rupestris L.（AR） on immune function in mice. Methods The immunomodulatory effect of AR was observed by delayed-type hypersensitivity（DTH） and the production of specific haemolysin antibody against fowl erythrocyte in serum.The effect of AR on murine proliferation of T,B lympholytes and phagocytotic function of abdominal macrophage was detected in vitro. Results AR had significant effect on the index of thymus and spleen the level of hemolysin induced by fowl erythrocyte immunization in serum,and improve the proliferation of T,B lympholytes and phagocytotic function of abdominal macrophage. Conclusion AR can increase the immune function specifically and nonspecifically.

关 键 词：一枝蒿 迟发型超敏反应 血清溶血素 免疫调节 

分 类 号：R285.5[医药卫生—中药学]