截短侧耳素分子印记聚合物吸附性能的初步研究  

Absorption Characteristics of the Molecule-Imprinted Polymer of Pleuromutilin

作　　者：王新杨[1] 任平平[1] 张丽颖[1] 仇文倩[1] 陈广通[1] 

机构地区：[1]南通大学医学院,江苏南通226000

出　　处：《时珍国医国药》2011年第4期825-828,共4页Lishizhen Medicine and Materia Medica Research

基　　金：江苏省高校自然科学基金(No.08KJD350003);江苏省大学生2008年创新项目;南通大学自然科学研究资金资助项目(No.07Z086)

摘　　要：目的探索人工模拟截短侧耳素分子生物受体的合成方法。方法利用分子印记聚合技术,采用凝胶法,以丙烯酰胺为功能单体,N,N′-亚甲基双丙烯酰胺为交联剂,初步制备了截短侧耳素的分子印迹聚合物;利用紫外光谱扫描法,测定其吸附溶液的光吸收度,对印迹聚合物的吸附特性进行了表征,同时也考察了不同单体用量对所制备的分子印迹聚合物的吸附性能的影响。结果与结论实验表明,制备的分子印迹聚合物对模板分子截短侧耳素吸附作用比无模板的聚合功能单体的吸附作用相对高26%~38%,说明制备的分子印迹聚合物有一定的吸附选择性,具备一定的分子受体特征。Objective To explore the synthetic method of artificial simulating receptor of pleuromutilin.Methods The molecule-imprinted polymer of pleuromutilin was primarily prepared with acrylatamide as monomer and N,N＇-MethylenebisAcrylamide as crossing-linker through molecularly imprinting technology on the gelatin method,and the absorbance value of its absorption solution was measured by UV spectrometerscopy,and the absorption characteristics of the molecule-imprinted polymer of pleuromutilin was also identified and the absorption effect of different quantities of monomers on the polymer was also observed.Results The absorption of the prepared molecularly imprinted polymer on the template molecule pleuromutilin was at up 26%～38% that of the non-imprinted polymer on the compound.Conclusion The molecule-imprinted polymer of pleuromutilin has certain selective absorption capacity for the template molecule and some characteristics of receptor of pleuromutilin.

关 键 词：分子受体 分子印记聚合物 截短侧耳素 吸附 

分 类 号：R283[医药卫生—中药学]