蜂王浆对环磷酰胺所致免疫低下小鼠免疫功能的影响  

Effects of Royal Jelly on Immunologic Function of Low Immune Mice Caused by Cyclophosphamide

作　　者：杨青[1] 石璐[1] 于晨[2] 范华英[1] 

机构地区：[1]烟台大学药学院,山东烟台264005 [2]滨州医学院药学院,山东烟台264005

出　　处：《时珍国医国药》2011年第4期840-842,共3页Lishizhen Medicine and Materia Medica Research

基　　金：山东省自然科学基金(No.Y2008C51)

摘　　要：目的探讨蜂王浆对环磷酰胺(CTX)所致免疫低下小鼠免疫功能的影响。方法建立小鼠免疫损伤模型,同时灌胃给予不同剂量蜂王浆连续7 d,以小鼠巨噬细胞吞噬功能、胸腺脾脏指数、迟发型超敏反应、血清溶血素水平为测定指标。结果蜂王浆3.06,6.12 g.kg-1剂量组能够明显增强小鼠巨噬细胞吞噬功能(P<0.05),同时,对小鼠胸腺脾脏指数具有一定的保护作用,并且能明显增加小鼠迟发型超敏反应,提高小鼠的血清溶血素含量。结论蜂王浆对CTX所致免疫低下小鼠免疫功能具有一定的增强作用。Objective To explore the effects of Royal Jelly on immunologic function of low immune mice caused by CTX.Methods The immunity-deficiency model was induced.Royaljelly（RJ） was continually intragastrically administered for 7 days with different dose,the macrophage phagocytic function,the thymus and spleen index,the delayed-type hypersensitive response and the serum hemolysin level were used as evaluated indexes to study the effects of RJ on immunologic function of low immune mice caused by CTX.Results 3.06 g·kg-1,6.12 g·kg-1RJ could significantly potentiate the macrophage phagocytic function,protect the index of thymus and spleen,enforce the delayed-type hypersensitive response,and improve the serum hemolysin level of mice.Conclusion RJ can strengthen the immunologic function of low immune mice caused by CTX.

关 键 词：蜂王浆 免疫 吞噬功能 迟发型超敏反应 溶血素 

分 类 号：R285.5[医药卫生—中药学]