生物碱类镇痛活性成分及其镇痛机制研究进展  

Advances in Studies on Analgesic Cukaloids and Their Analgesic Mechanism

作　　者：陶炳[1] 张奥[1] 蓝蓉[1] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081

出　　处：《时珍国医国药》2011年第4期957-960,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30600849);北京市科技新星资助(No.2007A108);985工程资助(中央民族大学985-3-3)

摘　　要：疼痛是一种因组织损伤或潜在的组织损伤而产生的痛苦感觉,它既是机体的一种保护性机制,也是临床许多疾病的常见症状。研究发现,从植物中提取得到的多种天然生物碱都具有镇痛活性且没有成瘾性而成为许多药物研究者的工作重点和中心。文章就近年来文献中报道的,具有明确化学结构,并且在体内外实验中显示有确切镇痛作用的天然产物,对其镇痛有效成分及机制进行了整理和综述。Pain is a result of tissue injury or potential tissue damage resulting from the felling of pain,it is not only a protective mechanism of the body,but also a common clinical symptom of many illnesses.The study found that a variety of natural alkaloids extracted from plants have analgesic activity and is not addictive,thus many researchers focus their study on this subject.This paper reviewed the analgesic effects of alkaloids with a definite chemical structure in vitro and in vivo,also reviewed their analgesic mechanisms.

关 键 词：镇痛药 生物碱 有效成分 镇痛机制 

分 类 号：R282.71[医药卫生—中药学]