愈骨疗伤胶囊提取工艺的优化  

Optimization of extraction process of Yuguliaoshang capsules

作　　者：孙艳[1,2] 卞俊[1] 许志仁[1,2] 陈海飞[1] 柳正良[1] 

机构地区：[1]解放军第411医院药学科,上海200434 [2]江西中医学院药学院,南昌333004

出　　处：《药学服务与研究》2011年第5期366-369,共4页Pharmaceutical Care and Research

基　　金：重大新药创制国家科技重大专项资助项目(No.2009ZXJ09004-058)

摘　　要：目的:建立愈骨疗伤胶囊的最佳提取工艺。方法:采用L9(33)正交试验法,用HPLC法以双波长同时测定川续断皂苷Ⅵ及柚皮苷的含量,以川续断皂苷Ⅵ及柚皮苷的转换率为评价指标,对水提、醇提和超声循环提取法进行比较。结果:醇提是最佳提取工艺,即加8倍量的55%乙醇,回流提取2次,每次1.5h。结论:该制备工艺合理、可行。Objective： To establish an optimal extraction process of Yuguliaoshang capsules.Methods： The orthogonal test [L9（33）] was used to select the optimal extraction process.The contents of asperosaponin Ⅵ and naringin were simultaneously determined by HPLC method with dual-wavelength detector.The conversion rates of asperosaponin Ⅵ and naringin were used as evaluation index.The extraction methods of water,ethanol and ultrasonic circulation were compared.Results： The optimal process was the ethanol extration.It was 1.5 h extraction with 8-fold volume of 55% ethanol for twice.Conclusion： The process is reasonable and feasible.

关 键 词：愈骨疗伤胶囊 柚皮苷 川续断皂苷Ⅵ 提取工艺 正交试验 色谱法 高效液相 

分 类 号：R943[医药卫生—药剂学]