圆锥石头花中两个具有α-葡萄糖苷酶抑制活性的新三萜皂苷(英文)  

Two New Triterpenoid Saponins from the Roots of Gypsophila paniculata with Potent α-Glucosidase Inhibition Activity

作　　者：姚舜[1,2] 罗建光[1] 马丽[1] 孔令义[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210038 [2]四川大学化学工程学院制药与生物工程系,成都610065

出　　处：《中国天然药物》2011年第6期401-405,共5页

基　　金：supported by the National Natural Science Foundation of China for Outstanding Young Scientists (No.30525032)~~

摘　　要：目的:研究圆锥石头花根中的化学成分。方法:用75%乙醇回流提取、乙酸乙酯和正丁醇依次萃取,采用硅胶、Sephadex LH-20、Rp-C18柱色谱法和制备液相色谱等方法分离纯化,根据光谱数据(一维、二维的核磁共振谱和质谱)及酸水解鉴定了化合物的结构并进行了-葡萄糖苷酶抑制活性测定。结果:从圆锥石头花根中分离得到2个新三萜多糖皂苷——圆锥石头花皂苷A(1)和B(2),两者均具有较强的α-葡萄糖苷酶抑制活性。结论:化合物1和2是首次从该植物中分离得到的新化合物,其结构中的对甲氧基-桂皮酰基可能为决定相关活性的关键基团。AIM：To investigate chemical constituents of Gypsophila paniculata.METHODS：The compounds were isolated by silica gel,Sephadex LH-20,Rp-C18 column chromatography and preparative liquid chromatography.Their structures were elucidated by ESI-MS,NMR techniques （1H,13C,HMQC,HMBC,TOCSY） and acid hydrolysis.Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone.RESULTS：Two triterpenoid saponins,caryophyllacosides A （1） and B （2）,were isolated from the roots of Gypsophila paniculata,without having recourse to chemical degradation or modification.Both of them were found to have potent α-glucosidase inhibitiory activity.CONCLUSION：The two triterpenoid saponins are new boactive compounds.

关 键 词：圆锥石头花 石竹科 三萜皂苷 葡萄糖苷酶抑制 

分 类 号：R284.1[医药卫生—中药学] R965.1[医药卫生—中医学]