掌叶大黄中的两个新化合物(英文)  

Two New Compounds from the Roots of Rheum palmatum

作　　者：李丽[1] 张村[1] 肖永庆[1] 陈东东[1] 田国芳[1] 王云[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国天然药物》2011年第6期410-413,共4页

基　　金：supported by the Key Program of the National Natural Science Foundation of China (No. 30730111)~~

摘　　要：目的:对掌叶大黄化学成分进行研究。方法:运用硅胶、聚酰胺、凝胶等柱层析等方法进行化合物的分离纯化,通过波谱分析和理化鉴别进行化合物的结构鉴定。结果:从掌叶大黄中分离鉴定了9个化合物,分别为2,5-二甲基-6,8-二羟基色原酮(1),1-甲基-2,8-二羟基-3-羧基-9,10-蒽醌(2),ω-羟基大黄素(3),4′-羟基苯基-2-丁酮(4),4′-羟基苯基-2-丁酮-4′-O-β-D-(2″-O-没食子酰基-6″-O-(4′′′-羟基)-桂皮酰基)-葡萄糖苷(5),反式-3,5,4′-三羟基二苯乙烯-4′-O-β-D-(6″-O-没食子酰基)-葡萄糖苷(6),4′-羟基苯基-2-丁酮-4′-O-β-D-(6″-O-桂皮酰基)-葡萄糖苷(7),4′-羟基苯基-2-丁酮-4′-O-β-D-(6″-O-(4′′′-羟基)-桂皮酰基)-葡萄糖苷(8),反式-3,5,4′-三羟基二苯乙烯-4′-O-β-D-葡萄糖苷(9)。结论:化合物1、2为新化合物。AIM：To study the constituents of Rheum palmatum.METHODS：Chromatographic separations of silica gel and polyamide were used.All the structures were elucidated on the basis of chemical and spectroscopic analysis.RESULTS：Nine compounds were isolated and their structure were identified as 2,5-dimethyl-6,8-dihydroxy-chromone （1）,1-methyl-2,8-dihydroxy-3-carboxy -9,10-anthraquinone （2）,citreorosein （3）,4-（4-hydroxyphenyl）-2-butanone （4）,4-（4-hydroxyphenyl）-2-butanone-4＇-O-β-D- （2″-galloyl-6″-O-p-coumaroyl）-glucopyranoside （5）,trans-3,5,4＇-trihydroxystilbene-4＇-O-β-D-（6″-galloyl）-glucopyranoside （6）,4-（4- hydroxyphenyl）-2-butanone-4＇-O-β-D-（6″-O-cinnamoyl）-glucopyranoside （7）,4-（4-hydroxyphenyl）-2-butanone-4＇-O-β-D-（6″-O-p-coumaroyl）-glucopyranoside （8）,trans-3,5,4＇-trihydroxystilbene-4＇-O-β-D-glucopyranoside （9）.CONCLUSION：Compounds 1 and 2 were newly isolated from Rheum palmatum.

关 键 词：掌叶大黄 2 5-二甲基-6 8-二羟基色原酮 1-甲基-2 8-二羟基-3-羧基-9 10-蒽醌 

分 类 号：R284.1[医药卫生—中药学]