2种不同基质的伤湿止痛膏的经皮渗透实验研究  

Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases

作　　者：闫小平[1] 官仕杰[1] 郑蕊[1] 伊博文[1] 王永刚 朱永红 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]甘肃奇正藏药集团,甘肃兰州730000

出　　处：《中国中药杂志》2011年第21期2960-2962,共3页China Journal of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划项目(2008BAI53B076)

摘　　要：目的:以伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品累积透过率为考察指标,研究新、旧2种不同基质的伤湿止痛膏的体外透皮特性。方法:利用改良扩散池进行体外透皮试验,用HPLC测定透皮接受液中马钱子碱、士的宁和硫酸阿托品含量。结果:新基质(热熔压敏胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品在72 h内平均累积透过率分别为53.25%,74.52%,34.32%;旧基质(天然橡胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品平均累积透过率分别为54.90%,50.24%,46.54%。结论:新基质较旧基质更利于亲脂性药物的释放,且释放更稳定。Objective： To study the percutaneous permeability 0f patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine. Method： Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC. Result： The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25% ,74. 52% were 34. 32%, respectively, and on old base are 54. 90%, 50. 24% ,46. 54%, respectively. Conclusion： The new base benefits the lipophilic drugs and releases more stably.

关 键 词：基质 伤湿止痛膏 经皮渗透 

分 类 号：R286.0[医药卫生—中药学]