三七总皂苷-丹参酮复合粒子的溶剂沉积法制备及其表征  

Preparation of notoginseng total saponins-tanshinone composite particles by solvent deposition method and their characterization

作　　者：付廷明[1] 杨丰云[1] 王天瑶[1] 王华美[1] 郭立玮[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210029

出　　处：《中草药》2011年第11期2216-2220,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(30973950)

摘　　要：目的为了解决粒子作为吸入载药系统,药物复方能同步传递的效果,制备出核/壳三七总皂苷-丹参酮复合粒子。方法在三七总皂苷粒子表面利用溶剂沉积法包覆一层丹参酮。分别利用扫描电镜(SEM)、X射线衍射(XRD)、差热分析(DTA)、激光光散射粒径扫描、高效液相色谱(HPLC)对复合粒子进行表征。结果通过上述表征,证明采用溶剂沉积法可成功制备包覆式复合粒子,即丹参酮包裹三七总皂苷复合粒子。结论复合粒子的有效制备为粒子载药系统复方药物的同步传递提供了有力保障,为复方粉雾剂的制备提供了技术支持。Objective To synchronously inhale Chinese materia medica compound using particle as inhalation drug delivery system, notoginseng total saponins-tanshinone composite particle was prepared. Methods The composite particle of notoginseng total saponins-tanshinone was prepared by solvent deposition method and was characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, differential thermal analysis （DTA）, particle size analysis, and high-performance liquid chromatography （HPLC）. Results The notoginseng total saponins-tanshinone composite particle was successfully prepared by solvent deposition method, the results of characterization proved that tanshinone was coated on the notoginseng total saponins core particle. Conclusion The preparation of composite particle provides an effective way for synchronous inhalation of Chinese materia medica compound prescription and technical support for the preparation of compound dry powder inhalations.

关 键 词：中药复方 复合粒子 表征 丹参酮 三七总皂苷 

分 类 号：R283.6[医药卫生—中药学]