瞬时波强技术评价糖尿病患者治疗前后颈动脉弹性功能改变的临床价值  

Clinical value of wave intensity to evaluate changes of arteria carotis elasticity in the patients with diabetes before and after therapy

作　　者：高宇[1] 王建华[1] 黄晓玲[1] 牛鑫鑫[2] 杨鹏飞[2] 张敏郁[1] 

机构地区：[1]北京军区总医院超声科,北京100700 [2]北京军区总医院内分泌科,北京100700

出　　处：《中华医学超声杂志（电子版）》2011年第7期52-55,共4页Chinese Journal of Medical Ultrasound(Electronic Edition)

摘　　要：目的探讨瞬时波强(WI)技术评价初诊2型糖尿病患者胰岛素泵强化治疗前后颈动脉弹性功能变化的临床应用价值。方法初诊2型糖尿病患者62例,应用WI技术检测其治疗前和胰岛素泵强化治疗2周后颈总动脉WI参数。另选择体检中心健康志愿者30例作为正常对照组,应用WI技术检测其颈总动脉WI参数。结果糖尿病组血管压力应变弹性模量(Ep)、血管硬化参数(β)、脉搏波传导速度(PWVβ)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)较正常对照组明显增高,瞬时加速度波强(W1)、瞬时减速度波强(W2)、血管顺应性(AC)明显减低,两组之间的差异有统计学意义(P<0.05)。糖尿病组强化治疗后Ep、β、PWVβ较治疗前减低,W1、W2、AC增高,差异有统计学意义(P<0.01,P<0.05)。结论 WI有助于临床评估药物治疗前后糖尿病患者血管弹性功能变化情况,能更客观地量化评估药物疗效。Objective To explore the clinical value of ultrasonic wave intensity（WI） technology evaluating the elasticity changes of arteria carotis in newly diagnosed patients with type 2 diabetes before and after intensive insulin therapy. Methods A total of 62 newly diagnosed patients with type 2 diabetes were enrolled. WI technology was applied to detect changes of arteria carotis parameters before and after two-week intensive insulin pump therapy. Thirty healthy volunteers from medical examination center were selected as the control group. WI technology was used to detect arteria carotis parameters. Results Compared with control group, the diabetes group had remarkable higher elasticity modulus （Ep）,stiffness parameter （β）,one point pulse wave velocity （PWVβ）, fasting blood sugar （FPG）, glycosylated hemoglobin （HbA1c） and lower accelerating wave intensity （W1）, decelerating wave intensity （W2）,arterial compliance （AC）,which had significant differences（P0.05）. After intensive therapy, the diabetes group had notable decreases in Ep,β,PWVβ and improvement in W1, W2,AC, which had significant differences（P0.01,P0.05）. Conclusion WI technology is beneficial to evaluate changes of blood vessel elasticity before and after medical therapy in patients with diabetes, which is more objective and quantitative in evaluation of treatment effects.

关 键 词：超声检查 2型糖尿病 胰岛素泵强化治疗 颈动脉 

分 类 号：R587.1[医药卫生—内分泌]