原发性肝癌患者DNA损伤修复酶基因多态性分析  

Genetic polymorphisms of DNA repair genes in patients with hepatocellular carcinoma

作　　者：唐耘天[1] 李辛平[1] 刘天奇[1] 杨建荣[1] 罗建强[1] 梁中骁[1] 

机构地区：[1]广西壮族自治区人民医院,南宁530021

出　　处：《山东医药》2011年第42期19-20,共2页Shandong Medical Journal

基　　金：广西医疗卫生重点科研课题基金资助项目(200963)

摘　　要：目的探讨DNA损伤修复酶基因多态性与原发性肝癌发生发展的关系。方法 PCR-RFLP法检测150例肝癌患者(肝癌组)和150例健康体检者(对照组)DNA损伤修复酶基因的表型,并进行比较。结果肝癌组XRCC1 Arg399Gln位点野生型的比率明显低于对照组(P<0.05);XRCC1(Arg194Trp、Arg280His)、hOGG1Ser326Cys位点多态性型别在两组中出现的频率相近(P>0.05);各基因位点不同表型者的尿8-羟基脱氧鸟苷(8-OHdG)水平相比,P均>0.05。结论 DNA修复酶基因多态性与肝癌的发生发展无明确的相关关系。Objective To investigate the relationship between genetic polymorphisms of DNA repair genes and hepatocellular carcinoma.Methods Genetic polymorphisms of DNA repair genes had been identified in 150 pateients with hepatocellular carcinoma（case group） and 150 healthy individuals（control group） by PCR-RFLP.Results Compared with control group,frequency of wild-type allele of X-ray repair cross complementing group 1（XRCC1） Arg399Gln is higher in case group.No significant difference of urinary 8-hydroxy-2-deoxyguanosine（8-OHdG） levels among different polymorphism genotypes in XRCC1 Arg194Tr,Arg280His,Arg399Gln and human 8-oxoguanine DNA glycosylase 1（hOGG1） Ser326Cys.Conclusion Genetic polymorphisms of DNA repair genes are not associated with hepatocarcinogenesis.

关 键 词：肝肿瘤 DNA修复基因 基因多态性 DNA氧化损伤 8-羟基脱氧鸟苷 X线修复交叉互补组1基因 人8-羟基鸟嘌呤修复酶基因 

分 类 号：R115[医药卫生—公共卫生与预防医学]