丹酚酸A对实验性糖尿病大鼠的降糖作用及其机制初探  

Anti-diabetic effect of salvianolic acid A and the possible mechanisms in rats with diabetes mellitus

作　　者：方莲花[1,2] 王月华[1] 何国荣[1] 杜冠华[1,2] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所国家药物筛选中心,北京100050 [2]中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国新药杂志》2011年第21期2063-2068,共6页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2009ZX09302-003;2009ZX09501-021);国家科技部基础性工作专项重点项目(2007FY130100);卫生部公益性行业科研专项(200902008;200802041)

摘　　要：目的:考察丹酚酸A对实验性糖尿病大鼠的降糖、降脂作用及其可能机制。方法:采用高糖高脂膳食4周诱导大鼠胰岛素抵抗后,腹腔注射亚致病剂量链脲佐菌素制备实验性糖尿病大鼠模型,观察丹酚酸A对血糖、血脂代谢的影响及其可能的机制。结果:连续灌胃给药8周,丹酚酸A可显著降低实验性糖尿病大鼠的空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白胆固醇及游离脂肪酸含量,显著增高实验性糖尿病大鼠血清超氧化物歧化酶活力,降低模型组大鼠丙二醛含量。结论:丹酚酸A不仅对实验性糖尿病大鼠血脂具有良好的调节作用,还能改善实验性糖尿病大鼠的血糖代谢,显著降低空腹血糖。Objective： To investigate the antidiabetic effect of salvianolic acid A （Sal A） and the possible mechanisms in rats with diabetes mellitus （DM）. Methods： DM was induced by intraperitoneally injection of streptozotocin in rats after feeding of the dietary that was rich in high fat and sucrose for 4 weeks. Results ： After 8- week oral-administration, the level of fasting blood glucose （FBG）, serum concentration of triglyceride, total cholesterol, low-density lipoprotein cholesterol and nonesterified fatty acid （NEFA） were significantly decreased in Sal A-treated rats compared with DM model rats. Superoxide dismutase activity was significantly increased and malondialdehyde content was significantly decreased in Sal A groups compared with DM model group. Conclusion： Sal A can decrease hyperlipidemia and improve glycometabolism by decreasing FBG in DM rats.

关 键 词：丹酚酸A 糖尿病 链脲佐菌素 机制 氧化应激 

分 类 号：R972.6[医药卫生—药品]