糖稳态的神经免疫内分泌调控轴及药物干预研究进展  

Progress in the research of neural-immune-endocrine axis for glucose homeostasis and the drug intervention

作　　者：马荣华[1] 黄洁[1] 闻晓东[1] 李萍[1] 

机构地区：[1]中国药科大学天然药物活性物质与功能国家重点实验室,南京210009

出　　处：《中国新药杂志》2011年第21期2100-2105,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30973884);教育部"长江学者和创新团队发展计划"(IRT0868)

摘　　要：以中枢神经系统为核心的神经免疫内分泌系统,通过HPA轴、肠-脑轴等调控通路共同维持机体糖稳态的平衡。系统研究多器官、多信号通路中葡萄糖、脂肪等物质的整体代谢调控机制,改善和恢复机体的物质代谢平衡,将为2型糖尿病等代谢性疾病提供一种全新的治疗思路和策略。The neural-immune-endocrine system in the central nervous system maintains the balance of the glucose homeostasis through the regulatory pathways such as the HPA axis and gut-brain axis. A systematic research on the overall metabolic control mechanism of glucose, fat and other substances in multi-organs and muhi-pathways may be useful in improving and restoring metabolism balance. It will provide new treatment ideas and strategies for metabolic disorders such as T2DM.

关 键 词：神经内分泌免疫调节网络 调控轴 糖稳态 

分 类 号：R589[医药卫生—内分泌]