动态心电图评价依帕司他对糖尿病心率变异性影响和疗效分析  

Effect of epalrestat on heart rate variability in diabetic patients

作　　者：林令华[1] 李志改[1] 于军会[1] 许金华[1] 孟凡霞[1] 

机构地区：[1]江苏省东海县人民医院药剂科,连云港222300

出　　处：《中国新药杂志》2011年第21期2130-2133,共4页Chinese Journal of New Drugs

基　　金：江苏省卫生厅临床药学科研课题项目(P200412)

摘　　要：目的:应用动态心电图评价依帕司他对糖尿病患者心率变异性的影响,确认依帕司他治疗糖尿病心脏自主神经病变的疗效。方法:收集糖尿病合并心脏自主神经病变患者100例,分为治疗组和对照组,治疗组患者口服依帕司他50 mg,tid,共8周。运用24 h动态心电图检测所有患者在治疗前后心率变异性指标的变化,观察依帕司他治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗2个疗程后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义。结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可改善患者心率变异性。Objective： To evaluate the effect of epalrestat on heart rate variability in diabetic patients Methods： Totally 100 diabetic patients with cardiac autonmic neuropathy were analyzed. The patients were treated with 50 mg epalrestat, 3 times a day for 8 weeks. The heart rate variability （HRV） in all patients was monitored with a 24-h hoher. Results： The indexes of HRV were significant improved after 8-week treatment. Conclusion： Epalrestat can improve HRV in diabetic patients, and it is an effective treatment of cardiac autonmic neuropathy.

关 键 词：依帕司他 糖尿病 心脏自主神经病变 心率变异性 动态心电图 

分 类 号：R587.1[医药卫生—内分泌]