对乙酰氨基酚在n-丁基吡啶六氟磷酸盐修饰碳糊电极上的灵敏测定(英文)  

Sensitive voltammetric determination of paracetamol based on ionic liquid n-butyl pyridinium hexafluophosphate modified carbon paste electrode

作　　者：娄广信[1] 张建福[1] 上官小东[1] 肖雪红[1] 党韶丽[1] 

机构地区：[1]宝鸡职业技术学院,陕西宝鸡721013

出　　处：《纺织高校基础科学学报》2011年第3期406-412,共7页Basic Sciences Journal of Textile Universities

基　　金：Supported by the Science Foundation of Baoji Vocational Technology College(20100013)

摘　　要：将离子液体(n-丁基吡啶六氟磷酸盐,[BuPy][PF6])与石墨粉混合,制备了离子液体修饰碳糊电极(CILE).在0.1mol/L醋酸盐缓冲溶液中(pH 4.7),采用循环伏安法(CV)、方波伏安法(SWV)及计时库仑分析法研究了对乙酰氨基酚的电化学行为.结果表明:CILE对对乙酰氨基酚的氧化还原具有明显的电催化作用;在0.1V/s扫速下,对乙酰氨基酚的氧化还原峰峰电位差(ΔEP)为88mV;扩散系数(D)为1.214×10-7 cm2/s.对乙酰氨基酚的氧化峰电流与其浓度在0.5～10.0μmol/L范围内呈线性关系(r=0.998 8),检出限为0.01μmol/L(S/N=3).该修饰电极成功用于片剂与尿样中对乙酰氨基酚含量的检测,且具有制作成本低、稳定性好、易于重复和制备等特点.A carbon ionic liquid electrode（CILE）,which was fabricated by mixing hydrophobic room temperature ionic liquid,n-butyl pyridinium hexafluophosphate（）,with graphite powder,was used to investigate the electrochemical behaviors of paracetamol in 0.1mol/L acetate buffer solution（pH 4.7） by cyclic voltammetry（CV）,square wave voltammetry（SWV） and chronocoulometry.The peak-to-peak potential separation（ΔEP） of paracetamol was 0.088 V with scan rate of 0.1V/s.The results showed that CILE exhibited better electrocatalysis for redox of paracetamol.Diffusion coefficient（D） was calculated as 1.214×10-7 cm2/s.The oxidation peak current versus concentration of paracetamol at CILE showed linearity in the range of 0.5-10.0 μmol/L（r=0.998 8） with a detection limit of 0.01μmol/L（S/N=3）.The proposed method was applied to determination of paracetamol in tablets and urine samples successfully.In addition,CILE was inexpensive,stable,repeatable and easy to be fabricated.

关 键 词：伏安法 电催化 碳离子液体电极 对乙酰氨基酚 

分 类 号：O651[理学—分析化学]