N-(末端三甲基硅脯氨酸肽链)邻苯二甲酰亚胺的光诱导单电子转移成环反应  

Photoinduced single electron transfer cycloreactions of N-(silane terminated proline peptide chain) phthalimide

作　　者：谭广慧[1] 郑鹏[1] 魏树权[1] 岳群峰[1] 曲凤玉[1] 金英学[1] 

机构地区：[1]哈尔滨师范大学化学化工学院,黑龙江哈尔滨150025

出　　处：《化学试剂》2011年第11期997-1000,共4页Chemical Reagents

基　　金：黑龙江省自然科学基金资助项目(B200913)

摘　　要：分子内单电子转移成环反应是有效地合成环化物的方法。以L-脯氨酸为起始原料合成了两个光反应底物N-(末端三甲基硅脯氨酸肽链)邻苯二甲酰亚胺,在其分子结构中,邻苯二甲酰亚胺基团为受电子体部分,末端三甲基硅脯氨酸肽链为给电子体部分,构成了分子内给受电子体系。N-(末端三甲基硅脯氨酸肽链)邻苯二甲酰亚胺在甲醇溶剂中进行了光反应,得到氮杂环脯氨酸肽。此反应产率较好,区域选择性高,所有新化合物结构均经NMR和FAB-MS验证。Two photoreactants N-（ silane terminated proline peptide chain） phthalimide were synthesized by using proline as the starting material. The phthalimido group was the electronic accept,and amidosilane terminated polyproline peptides were the electronic donors in these moleculars. N-（ silane terminated proline peptide chain） phthalimide were irradiated in methanol to give the title compound cyclopeptides in high yield and high regioselectivity. Structures of all compounds were characterized by FAB-MS, NMR.

关 键 词：光诱导 单电子转移 L-脯氨酸 环肽 区域选择性 

分 类 号：O621.25[理学—有机化学]