紫杉醇联合卡铂化疗对非小细胞肺癌患者免疫功能及医院感染的影响  

Effect of paclitaxel and carboplatin chemotherapy on immunologic function and nosocomial infection in patients with non small cell lung carcinoma

作　　者：胡娅[1] 唐曦[2] 

机构地区：[1]长江大学医学院机能学部,湖北荆州433020 [2]华中科技大学同济医学院附属荆州医院肿瘤科,湖北荆州433020

出　　处：《中华医院感染学杂志》2011年第22期4740-4741,4718,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨紫杉醇联合卡铂化疗对非小细胞肺癌(NSCLC)患者免疫功能及医院感染的影响。方法 229例NSCLC患者采用紫杉醇联合卡铂化疗,观察不良反应、对免疫功能和医院感染的影响。结果 214例完成该研究,Ⅲ、Ⅳ级白细胞减少45例占21.03%,血小板减少18例占8.41%,贫血12例占5.61%,医院感染23例占10.75%;化疗后CD4+、CD8+和CD4+/CD8+明显下降,与化疗前比较差异有统计学意义(P<0.05),化疗后感染组各指标低于非感染组,差异有统计学意义(P<0.05);共分离出26株病原菌,革兰阴性菌19株占73.08%、革兰阳性菌4株占15.38%和真菌3株占11.54%;分布较多的为大肠埃希菌占26.92%和铜绿假单胞菌占19.23%。结论化疗药物可引起严重的不良反应,降低免疫功能,并加重医院感染的发生。OBJECTIVE To explore the role of paclitaxel and carboplatin on immunologic function and nosocomial infection in patients with non small cell lung carcinoma（NSCLC）. METHODS A total of 229 cases with NSCLC were selected,and they were treated with paclitaxel and carboplatin.The toxic effects,immunologic function and nosocomial infection were evaluated. RESULTS Total of 214 cases were followed up.The status of toxic effects grade Ⅲ and Ⅳ were as follows：45 cases（21.03%） with leucopenia,18 cases（8.41%） with platelets decrease,and 12 cases（5.61%） with anemia.Nosocomial infection occurred in 23 cases（10.75%）.The value of C4＋,CD8＋ and CD4＋/CD8＋ were dropped significantly after chemotherapy（P〈0.05）,and there was aslo a significant difference between infectious group and uninfection group（P〈0.05）.26 stranis of pathogens were isolated with 19（73.08%） of Gram-negative bacteria,4（15.38%） of Gram-positive bacteria,and 3（11.54%） of fungi.Escherichia coli（26.92%） and Pseudomonas aeruginosa（19.23%） were the main pathogens. CONCLUSION Chemotherapeutics can cause serious toxic effects,reduce the immunologic function,and increase the incidence of nosocomial infection.

关 键 词：非小细胞肺癌 化疗 免疫功能 医院感染 

分 类 号：R181.302[医药卫生—流行病学]