门诊泌尿系感染病原菌分布及耐药性分析  

Distribution and antimicrobial resistance of pathogens causing urinary tract infections in outpatients

作　　者：赵锐[1] 杨文航[2] 张力[1] 齐宏[1] 蔡晶[1] 张秋红[1] 张丽民[1] 唐凤强[1] 徐英春[2] 

机构地区：[1]华北电网有限公司北京电力医院检验科,北京100073 [2]中国医学科学院北京协和医院检验科,北京100730

出　　处：《中华医院感染学杂志》2011年第22期4839-4841,共3页Chinese Journal of Nosocomiology

基　　金：卫生部政策法规司资助项目(20111003)

摘　　要：目的分析门诊泌尿系感染(UTI)患者分离病原菌的分布及耐药性。方法收集门诊尿常规阳性的UTI患者的清洁中段尿标本,进行细菌培养,采用纸片扩散法进行体外药敏试验,用WHONET软件分析药敏结果。结果引起门诊UTI感染主要病原菌是大肠埃希菌占74.2%,大肠埃希菌对氨苄西林的耐药率最高为69.6%,超广谱β-内酰胺酶(ESBLs)检出率为24.7%,未检测到对亚胺培南、美罗培南、阿米卡星、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦耐药的菌株。结论了解门诊泌尿系感染的病原菌分布及耐药性至关重要,可以为临床医师提供经验治疗UTI的病原学依据。OBJECTIVE To investigate distribution and antimicrobial susceptibility of pathogens isolated from outpatients with urinary tract infections. METHODS The clear midstream urine samples from outpatients with UTI were collected and cultured,when routine urine test was abnormal.Antimicrobial susceptibility tests was performed according to Disk Diffusion method recommended by CLSI,and results were analyzed with WHONET software. RESULTS Escherichia coli was the predominant species（74.2%） causing UTI amongst outpatients.The resistance rate of E.coli to ampicillin was the highest（69.6%）,and 24.7% of E.coli isolate were detected to be extended-spectrum beta-lactamases（ESBLs） producers.Further,no E.coli isolates was resistant to impenem,meropenem,amikacin,cefoperazone-sulbactam or piperacillin-tazobactam. CONCLUSION To understand the local epidemiology and susceptibility of pathogens causing UTI amongst outpatients is of great importance,and it can help clinicians in local hospital to initiate appropriate empirical antibiotic therapy of UTI.

关 键 词：泌尿系感染 病原菌 耐药性 大肠埃希菌 

分 类 号：R378[医药卫生—病原生物学]