核糖体RNA二级结构对拓扑结构准确性的影响(英文)  

Effects of rRNA secondary structure on topological accuracy:a case study based on fungal 18S rRNAs

作　　者：刘超洋[1,2] 庄文颖[2] 

机构地区：[1]西南科技大学生命科学与技术学院,绵阳621010 [2]中国科学院微生物研究所真菌学国家重点实验室(筹),北京100101

出　　处：《菌物学报》2011年第6期912-919,共8页Mycosystema

基　　金：Supported by the Talent Grant of Southwest University of Science and Technology to CYL;the National Natural Science Foundation of China (No. 31070015);the Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-EW-J-6) to WYZ

摘　　要：探讨了核糖体小亚基二级结构对真菌系统发育分析的影响。对用不同方法构建的系统发育树进行比较,结果表明结合二级结构信息的分析方法较传统方法产生了更为合理的拓扑结构。二级结构信息除用于优化序列比对外,还需整合到核酸替代模型中;恰当的序列比对方法、进化模型和建树运算法则有助于更加准确地揭示类群之间的亲缘关系。Different methods using rRNA secondary structure to assist phylogenetic analyses have been recently developed.In order to evaluate the structure information on accuracy of phylogenetic tree topology,comparisons of these methods were performed.Our results showed significant superiority of phylogenetic analyses incorporating secondary structure over the pure traditional approaches.When the three major factors,alignment method,evolutionary model and tree search algorithm,were considered simultaneously in phylogenetic analyses,the implementation of structure information in alignment and substitution model produced a noticeable positive effect on topological accuracy.

关 键 词：系统发育 序列分析 拓扑结构 

分 类 号：Q943[生物学—植物学]