延胡索对吗啡依赖大鼠条件性位置偏爱效应的影响  

Influence of Corydalis yanhusuo W.T.Wang on Morphine-induced Conditioned Place Preference

作　　者：吴明松[1] 郭萍[1] 钱刚[1] 杨明理[1] 黄彬[1] 罗素元[1] 

机构地区：[1]遵义医学院,贵州遵义563003

出　　处：《时珍国医国药》2011年第6期1300-1301,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30860373)

摘　　要：目的观察延胡索水提液对吗啡诱导条件性位置偏爱(CPP)效应的影响。方法吗啡剂量递增颈背部皮下注射10 d,建立大鼠吗啡CPP模型。在CPP测试后当日,不同剂量延胡索水提液灌胃治疗。结果在延胡索1 mg·kg-1,2 mg·kg-1组,大鼠吗啡CPP效应6 d消退,相比模型组(21 d消退)提前2/3时程。结论延胡索单味中药能加速吗啡诱导CPP效应的消退,提示该药具有治疗吗啡精神依赖的潜能。Objective To study the effect of Corydalis yanhusuo W.T.Wang on morphine-induced conditioned place preference（CPP）.Methods SD rats were injected with morphine（sc） and trained for 10 days in order to set up the model of morphine-induced CPP,and then administered with C.yanhusuo W.T.Wang（ig） for 14 days.Results After treatment with C.yanhusuo W.T.Wang at the doses of 1mg·kg-1 and 2mg·kg-1 for six days,the CPP was extinguished obviously.Compared with untreated control group,the extinguished CPP was ahead of 15 days.Conclusion C.yanhusuo W.T.Wang can stimulate the attenuation of CPP,and C.yanhusuo W.T.Wang might be a potential treatment for morphine-induced psychological dependence.

关 键 词：延胡索 吗啡 条件位置偏爱 

分 类 号：R285.5[医药卫生—中药学]