人参皂苷生物合成途径的初步研究  

Preliminary Study of Biosynthetic Pathway of Ginsenoside

作　　者：郜玉钢[1] 王亚星[1] 臧埔 李学[1] 李萍[1] 张连学[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《时珍国医国药》2011年第10期2422-2423,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30570185);博士后基金(No.20090461042);国家科技支撑计划(No.2007BAI38B01)

摘　　要：目的探讨人参皂苷生物合成途径。方法测定不同浓度的光灭灵和ATP对人参皂苷生物合成的影响。结果广灭灵抑制人参皂苷生物合成,ATP促进人参皂苷生物合成。结论人参皂苷苷元的合成经由甲羟戊酸→三十碳六烯→牻牛儿基二磷酸途径,异戊烯二磷酸异构酶和异戊烯基转移酶是人参皂苷生物合成途径的两个重要的酶。ObjectiveTo investigate the biosynthetic pathway of ginsenoside. MethodsThe influence of clomazone and ATP to ginsenoside biosyntheisi in different concentrations was determined. ResultsClomazone inhibited the biosynthesis of ginsenoside,ATP promoted the biosynthesis of ginsenoside. ConclusionGinsenoside was synthesized by the pathway of mevalonic acid→thirty C six alkene→gernyl diphosphate.Isopentenyldiphosphate isomerase and isopentenyl transferase are tow key enzymes of the biosynthetic pathway of ginsenoside.

关 键 词：人参 皂苷 关键酶 合成途径 

分 类 号：R284.3[医药卫生—中药学]