正交实验法优选两面针的提取工艺研究  

Optimization of Extraction Technology of Zanthoxylum niridum(Roxb.) DC. by Orthogonal Test

作　　者：雷欣潮[1] 刘华钢[2] 赖茂祥[3] 郑娟梅[1] 管志萍[1] 

机构地区：[1]广西中医学院,广西南宁530001 [2]广西医科大学,广西南宁530021 [3]广西中医药研究院,广西南宁530022

出　　处：《时珍国医国药》2011年第10期2494-2495,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30760302);广西壮族自治区科技攻关与新产品试剂(No.0992003A-21);广西壮族自治区科技厅项目(No.0832127)

摘　　要：目的优选两面针的提取工艺。方法采用正交设计实验法,以氯化两面针碱、乙氧基白屈菜红碱、L-芝麻素的含量为指标,多指标综合评分法进行数据分析,优选提取条件。结果两面针的最佳提取工艺为加入80%的乙醇提取3次,每次14倍量乙醇,每次提取1 h。结论优选出的最佳工艺条件合理、稳定,指标性成分含量高,可以用于生产。ObjectiveTo optimize extraction technology of Zanthoxylum niridum（Roxb.） DC. MethodsIn the method of orthogonal design test,the contents of nitidine chloride,ethoxychelerythrine and L-sesamin were used as indexes.Data analysis was carried out with the Comprehensive Evaluation of Multi-targets for optimizing the extraction condition. ResultsThe optimal extraction technology was to extract for 3 times with 14-fold ethanol solution（80%）,and 1 h each time. ConclusionThe optimal extraction technology is rational and stable,and the contents of components for maker are high.

关 键 词：两面针 正交设计 提取工艺 综合评分法 

分 类 号：R284.2[医药卫生—中药学]