利培酮合并舍曲林对强迫症患者疗效的影响  

Effects of Risperidone Combining with Sertraline on Obsessive-compulsive Disorder

作　　者：赵玉香[1] 张艳华[1] 余学[1] 

机构地区：[1]中国．驻马店市精神病医院,463000

出　　处：《中国健康心理学杂志》2011年第10期1196-1197,共2页China Journal of Health Psychology

摘　　要：目的探讨利培酮合并舍曲林治疗强迫症的疗效。方法将符合条件的80例强迫症患者随机分成利培酮合并舍曲林组和单用舍曲林组,各40例,观察8周。采用耶鲁-布郎强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAM D)评定疗效。结果治疗结束后两组Y-BOCS、HAMA、HAM D的评分均显著降低,而合用组更为明显,合用组和舍曲林组比较Y-BOCS(t=2.61)、HAMA(t=2.48)、HAM D(t=2.54)评分治疗后有显著性差异(P均<0.05)。结论利培酮合并舍曲林治疗强迫症可以增强疗效。Objective To explore the effect of risperidone combining with sertraline on patients with obsessive-compulsive disorder（OCD）.Methods A total of 80 patients with OCD were randomly treated with risperidone combining with sertraline（n=40） or sertraline only（n=40）.The efficacy was measured with Yale-Brown obsessive Compulsive Scale（Y-BOCS）,Hamilton anxiety scale HAMA）and Hamilton Depression Scale（HAMD）.Results After treatment,there were significant differences between two groups in the reduction rate of Y-BOCS,HAMA and HAMD total scores.There were significant differences between combined group and sertraline group at the scores of Y-BOCS（t=2.61）,HAMA（t=2.48）,HAMD（t=2.54） in the end of the study（P all 0.05）.Conclusion Risperidone combining with sertraline have a superior effectiveness in treating OCD.

关 键 词：利培酮 舍曲林 强迫症 疗效 

分 类 号：R971.4[医药卫生—药品]