精神分裂症患者一级亲属脑组织磁共振质子波谱成像的初步研究  

Primary Study on Brain Tissue Proton Magnetic Resonance Spectroscopy Imaging of First-degree Relatives of Patients with Schizophrenia

作　　者：李旭文 杜秀娟 张雄 

机构地区：[1]内蒙古林业总医院医学影像中心,中国牙克石022150 [2]呼伦贝尔市精神卫生中心

出　　处：《中国健康心理学杂志》2011年第10期1197-1199,共3页China Journal of Health Psychology

摘　　要：目的探讨精神分裂症患者一级亲属及正常对照组脑组织磁共振质子波谱分析(1H-M RS)的结果间是否存在差异。方法首先对精神分裂症患者一级亲属36人、正常对照组21人进行左侧前额叶、丘脑、海马、桥脑的1H-M RS分析,之后对所得结果进行独立样本t检验。结果精神分裂症患者一级亲属与正常对照组在左侧前额叶、丘脑、海马、桥脑的1H-M RS检查结果存在一定差异但均无统计学意义(t=-1.63,P>0.05)。结论精神分裂症患者一级亲属与正常对照组在本实验所选择的感兴趣区内未发现可测的神经化学物质浓度变化。Objective To investigate whether results of brain tissue proton magnetic resonance spectroscopy analysis（1H-MRS） between first-degrss relatives of schizophrenic patients and normal control group had difference.Methods A total of 36 first-degrss relatives of schizophrenic patients and 21 people in normal control group accepted left prefrontal cortex,thalamus,hippocampus and pon brain 1H-MRS analysis,and then the results acceptted independent sample t test.Results The 1H-MRS test results of left prefrontal cortex,thalamus,hippocampus and pon brain between first-degrss relatives of schizophrenic patients and normal control group had not significant differences（t=-1.63,P0.05）.Conclusion No detectable neurochemical substance concentration changes are discovered in the interest zones selected by the test between first-degrss relatives of schizophrenic patients and normal control group.

关 键 词：精神分裂症患者一级亲属 磁共振质子波谱成像 磁共振质子波谱分析 

分 类 号：R742.1[医药卫生—神经病学与精神病学]