维生素K3对尿路结石病人尿中骨桥蛋白浓度的影响  

Effect of Vitamin K3 on the concentration of osteopontin in the urine of the patients suffered from urolithiasis

作　　者：赵国防[1] 李民[1] 刘美云[1] 

机构地区：[1]中山大学附属东华医院泌尿外科（外九科）,广东东莞523013

出　　处：《中国中医药咨讯》2011年第21期23-24,共2页

基　　金：本课题为广东省东莞市医疗卫生科技计划项目（项目编号200207）

摘　　要：目的：探讨维生素l（3对尿路结石病人尿中骨桥蛋白浓度的影响；从而观察维生素K3对尿路结石病人的治疗和预防复发的效果。方法：随机选取30例尿路结石患为维生素K组，肌注维生素K312mg／d，连续7天；收集用药前后的尿标本；随机选30例正常人做对照组，收集尿标本；利用westernblotting技术测定各尿标本中的骨桥蛋白含量；比较尿路结石患者用药前后及与正常人尿中骨桥蛋白含量的差别。统计学方法：配对资料均数t检验。结果：维生素K组用药后比用药前尿中骨桥蛋白含量高18．7％（P〈0．05）；用药前组比正常对照组尿中骨桥蛋白含量高93％，但差别无统计学意义（P=0．036）；用药后组比正常对照组尿中骨桥蛋白含量明显升高129％（P=0．0045，〈0．01）。结论：临床应用维生素K可上调肾骨桥蛋白的表达，抑制结石的形成，对尿路结石的治疗和预防有一定效果，值得推广。Objective To investigate the effect of Vitamin K on concentration of osteopontin in the urine of patients suffered from urolithiasis; To investigate the effect of vitamin K in treating and preventing urolithiasis. Methods 30 patients who were suffered from urolithiasis were treated with vitamin K3 injection（ 12mg/d,for 7days） ; 30 normal persons for comparing; all urine specimens were collected in patients before and after treatment and in normal persons, respectively. The concentration of osteopontin in urine were detected with Western blotting..Statisties analysis is t test. Results The concentration of osteopontin in urine were 18.7% higher after vitamin K3 treated （P 〈 0.05）. The concentration of osteopontin in urine in group vitamin K before vitamin K used were 93% higher than normal group, but there was no siguifieanee in statistics （P=0.36）. The concentration of osteopontin in urine in group vitamin K after vitamin K used were 129% higher than normal group,（P=0.045,P 〈 0.05）.Conclusion Vtamin K can clinically up-regulate the expression of OPN （osteopontin）, and inhabit the formation of urolithiasis. Vtamin K have exact effect in treating and preventing urolithiasis, and could be extensively rec ommended.

关 键 词：维生素K 雌二醇 尿路结石 骨桥蛋白 肾 

分 类 号：R977.26[医药卫生—药品]