钙调磷酸酶抑制剂治疗银屑病研究进展  

Calcineurin inhibitors in the treatment of psoriasis

作　　者：文晓婷[1] 魏志平[1] 刘彦群[1] 

机构地区：[1]江苏省徐州医学院附属医院皮肤科,221002

出　　处：《国际皮肤性病学杂志》2011年第6期346-348,共3页International Journal of Dermatology and Venereology

摘　　要：钙调磷酸酶抑制剂可阻断钙调磷酸酶的信号通路，抑制T细胞的活化，以往主要作为免疫抑制剂用于器官移植后的免疫调节治疗。近年的研究发现其对一些炎症性皮肤病，如银屑病和特应性皮炎等同样有效，外用疗效接近糖皮质激素却不会导致皮肤萎缩，他克莫司软膏和吡美莫司乳膏有望成为外用糖皮质激素在银屑病治疗中的替代药物。概述几种钙调磷酸酶抑制剂治疗银屑病的临床疗效、作用机制以及其不良反应。Calcineurin inhibitors can block calcineurin signaling pathway, thereby suppress T- cell activation. In the past, it was used as an immunosuppressant for immunoregulation after organ transplantation. Recent studies have found that they are also effective for the treatment of some inflammatory skin diseases such as psoriasis and atopic dermatitis. Their efficacy is close to that of cortieosteroids but they do not induce skin atrophy. Tacrolimus ointment and pimecrolimus cream are expected to be an alternative to topical corticosteroids in the treatment of psoriasis. This review presents the clinical efficacy, mechanism of action and side effects of several calcineurin inhibitors in the treatment of psoriasis.

关 键 词：银屑病 钙调磷酸酶抑制剂 治疗 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]