宿主氧化损伤及致病真菌抗氧化损伤机制的研究进展  

Mechanisms for host oxidative damage to and anti-oxidative stress response by pathogenic fungi

作　　者：宗丽娜[1,2] 李海涛[1] 杨蓉娅[1] 

机构地区：[1]北京军区总医院全军皮肤病诊治中心,100125 [2]山西医科大学

出　　处：《国际皮肤性病学杂志》2011年第6期383-385,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81071304）

摘　　要：病原体入侵机体后，诱导机体进入一种氧化应激状态，吞噬细胞释放大量活性氧介质，当活性氧介质的产生和清除存在不平衡时，会造成细胞氧化损伤。而病原体本身在遇到氧化应激时也表达一些抗氧化物质，来启动抗氧化机制，以降低氧化损伤对其杀伤和破坏。阐述宿主释放的活性氧介质如过氧化氢、超氧阴离子、羟自由基等对致病真菌的氧化损伤，以及致病真菌表达抗氧化物质如过氧化氢酶、超氧化物歧化酶等抗氧化损伤的机制。Invading pathogens can induce the host into a state of oxidative stress followed by the release of massive reactive oxygen species by phagocytes. Once the balance between the generation and removal of reactive oxygen species is disturbed, oxidative damage to cells occurs. When confronting oxidative stress, pathogens express some antioxidants to trigger the anti-oxidative mechanisms and counteract the killing and damage mediated by oxidative stress. This review expounds the mechanisms underlying the oxidative damage to pathogenic fungi by reactive oxygen species released from hosts, such as hydrogen peroxide, superoxide anion, hydroxyl radical, etc, and anti-oxidative stress response mediated by antioxidants such as catalase and superoxide dismutase expressed by pathogenic fungi.

关 键 词：真菌 活性氧 抗氧化剂 

分 类 号：R285.5[医药卫生—中药学]