乙型肝炎病毒宫内感染中母胎外周血单核细胞的转运机制  

Maternal-fetal transfer mechanism of peripheral blood mononudear cells in hepatitis B virus intrauterine infection

作　　者：魏俊妮[1] 王素萍[1] 

机构地区：[1]山西医科大学流行病学教研室,太原030001

出　　处：《国际流行病学传染病学杂志》2011年第5期329-332,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家自然科学基金（30901227）;山西省基础研究计划（2011021038-3）;山西省高等学校科技研究开发项目（20091114）;山西医科大学青年基金（02200705）

摘　　要：研究宫内感染的机制对降低我国HBsAg慢性携带率具有非常重要的意义。妊娠过程中母体血液中的血小板和白细胞可通过胎盘屏障，而胎盘细胞凋亡与胎盘屏障通透性增加又存在不可分割的内在联系，PBMC是HBV肝外感染的主要细胞，在HBV复制、感染及迁延中起着重要作用，可以作为HBV的载体。这些证据提示PBMC母胎转运在HBV宫内感染中可能具有不容忽视的作用。此文对HBV宫内感染的定义及判定指标、感染的机制及危险因素、母胎PBMC转运机制与感染的关系等进行综述。It has great significance to study mechanism of intrauterine infection in reducing the chronic HBsAg carrier rate in China. Maternal blood platelets and white blood cells can pass through the placental barrier during pregnancy. The indivisible intrinsic link exists between placental apoptosis and placental barrier permeability increase. PBMC is mainly extrahepatic cells in HBV infection,it plays an important role in HBV replication, and persistent infection. It may be as carriers of HBV. The evidence suggests that role of maternal-fetal PBMC transfer in HBV intrauterine infection can not be ignored. In this paper, the definity and diagnostic index of HBV intrauterine infection, the infected mechanisms and risk factors, the relation between maternal-fetal transfer mechanisms of PBMC and the infection are reviewed.

关 键 词：肝炎病毒 乙型 宫内感染 母胎转运 外周血单核细胞 

分 类 号：R714[医药卫生—妇产科学]