结直肠癌肿瘤相关性贫血相关因素综合分析  

Comprehensive Analysis of Relevant Factors on Colorectal Cancer-related Anemia

作　　者：葛军娜[1] 于健春[1] 康维明[1] 马志强[1] 古应超[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院基本外科,北京100730

出　　处：《中国医学科学院学报》2011年第5期549-554,共6页Acta Academiae Medicinae Sinicae

基　　金：卫生部国家科技支撑计划(2008BAI58B02)~~

摘　　要：目的分析结直肠癌肿瘤相关性贫血的相关因素。方法回顾性分析319例结直肠癌患者的临床资料,综合分析结直肠癌的部位、分期、临床症状、病理学、性别、年龄等因素与结直肠癌合并贫血的相关性。结果 319例结直肠癌的总体贫血发生率为44.20%,其中62.20%右半结肠癌患者合并贫血;23.82%直肠癌患者合并贫血,横结肠、降结肠、乙状结肠贫血的总发生率为36.23%。心功能不全、黑便、右半结肠、肿瘤T分期、白蛋白血症是结直肠癌贫血的相关因素,低蛋白血症和右半结肠时结直肠癌围手术期输血的比值比分别是3.004和8.356。结论结直肠癌贫血的发生与肿瘤临床分期无相关性,心功能不全、低蛋白血症、黑便、T分期、右半结肠癌是结直肠癌贫血的相关因素,而贫血和低蛋白血症是结直肠癌围手术期输血的相关因素。Objective To analyze the risk factors of colorectal cancer-related anemia.Method The clinical data of 319 patients with colorectal cancer were retrospectively analyzed for the possible risk factors of tumor-related anemia including tumor location,clinical stage,clinical symptoms,pathology,gender,and age.Results Of these 319 cases,141（44.20%） had anemia.The incidence of anemia was 62.20% among patients with right hemicolon cancers（including caecum cancer）,and was 23.82% among patients with rectal cancer and 36.23% among those with transverse descending or sigmoid colon cancer.Cardia insufficiency,melena,tumor location,T staging,hypoproteinemia were also found to be related with anemia.Anemia and hypoproteinemia were the risk factors for perioperative blood transfusion（odds ratio=3.004,odds ratio=8.356,respectively）.Conclusions The colorectal cancer-related anemia is not associated with the clinical stage of the tumor,while cardiac insufficiency,melena,tumor location,tumor stage,and hypoproteinemia constitute the possible risk factors.Anemia and hypoproteinemia are the risk factors of perioperative blood transfusion.

关 键 词：肿瘤相关性贫血 结直肠癌 低蛋白血症 

分 类 号：R735.3[医药卫生—肿瘤]