胺碘酮治疗急性冠脉综合征伴快速房颤疗效与观察  

Observation on therapeutic effect of amiodarone for fast atrial fibrillation in patients with acute coronary syndrome

作　　者：夏野[1] 朱友群[1] 刘欢年[1] 王宇栋[1] 

机构地区：[1]常州市第四人民医院,江苏常州213001

出　　处：《中外医学研究》2011年第32期7-9,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨静脉应用胺碘酮对急性冠脉综合征(ACS)伴快速房颤患者的临床疗效。方法 41例ACS伴新发快速房颤患者,先静脉注射胺碘酮,负荷量150mg,然后以0.5～1.0mg/min静脉滴注维持,观察房颤转复、心室率控制及副作用。结果 41例患者用药后15min、1h、2h、24h心室率分别是(138.9±13.9)次/min、(122.7±9.6)次/min、(104.3±8.3)次/min、(87.1±12.8)次/min,较用药前(144.6±13.4)次/min下降(P<0.05)。其中24h转复率78.05%(32/41),2例用药后出现长R-R间期,2例出现窦性心动过缓,经减量或停药后恢复。结论静脉应用胺碘酮对急性冠脉综合征(ACS)伴快速房颤患者安全有效。Objective To observe the effect of amiodarone to fast atrial fibrillation in patients with acute coronary syndrome （ACS）. Methods Forty -one ACS patients with newly onset fast atrial fibrillation were observed. After a load dose （150 mg）, intravenous amiodarone was administered continuously. Efficacy of amiodarone in there version of atrial fibrillation and the control of ventricular rate as well as the side effects were observed. Results The ventricular rate 15 min, 1 hour,2 hour,24 hour after the administration of amiodarone in the 41 patients was （ 138. 9 ±13.9） beats/min, （ 122. 7 ±9. 6） beats/min, （ 104. 3 ±8.3 ） beats/min, （ 87.1 ±12. 8 ） beats/min respectively, lowered than the rate （144. 6 ±13.4 ）beats/rain before the drug was given （P 〈 0. 05 ）. Atrial fibrillation was reverted to sinus rhythm with 24 hour in 32 of 41 cases （78.05%）. Long R - R inter mitment observed in 2 patients, sinus bradyeardia was occurred in 2 patients, cardiac rhythm in all the patients＇returned to normal after reducing the dose or ceasing the medicine. Conclusion Intravenous amiodarone is effective and safe in the treatment of fast atrial fibrillation in patients with ACS.

关 键 词：急性冠脉综合征 心房颤动 胺碘酮 

分 类 号：R541.4[医药卫生—心血管疾病]