UTS_2-T21M基因多态性与甘肃不同性别人群原发性高血压的关系  

Association of Urotensin II(UTS2) T21M polymorphisms with different gender essential hypertension in Gansu population

作　　者：张冬蕾[1] 伊琳[2] 

机构地区：[1]兰州大学校医院,甘肃兰州730000 [2]甘肃中医学院

出　　处：《中国老年学杂志》2011年第20期3914-3915,共2页Chinese Journal of Gerontology

基　　金：甘肃省自然科学基金资助项目(1010RJ2A158)

摘　　要：目的研究硬骨鱼紧张素ⅡT21M基因(UTS2-T21M)单核苷酸多态性(SNP)与甘肃不同性别原发性高血压的关系。方法用PCR-RFLP及电泳分析法进行基因分型;SPSS软件分析各基因型与不同性别人群原发性高血压的相关性。结果研究包括318例原发性高血压患者,其中男性174例,女性144例。233例正常人中男性134例,女性99例。男性高血压患者与女性高血压患者在基因型,等位基因频率上均无显著差异(P=0.443,0.490)。UTS2-T21M多态性,TT,TM,MM基因型的频率在男性病例组中分别25.3%,55.7%,19.0%;在女性病例组中相应基因型的频率为31.3%,49.3%,19.4%。T,M等位基因频率在男性病例组中分别53.2%,46.8%,在女性病例组中相应的等位基因频率为55.9%,44.1%。结论 UTS2-T21M基因多态性与甘肃不同性别人群原发性高血压无关,有关UTS2-T21M基因多态性与甘肃不同性别原发性高血压的关系。Objective To study the association of UTS2-T21M SNP with different gender essential hypertension in Gansu population.Methods Genotyping of UTS2-T21M was conducted with PCR-RFLP and agarose gel electrophoretic analysis.All statistical analyses were performed with SPSS for Windows.Results 318 essential hypertension（EH） cases including 174 male and 144 female were studied.233 healthy controls were studied including 134 male and 99 female.There was no significant difference in genotypic and allelic frequency of T21M SNP in UTS2 between male and female EH patients（P=0.443,and 0.490,respectively）.Frequencies of TT,TM,MM genotypes were 25.3%,55.7%,19.0% in male EH,and 31.3%,49.3%,19.4% in female EH.Frequencies of T,M allele were 53.2%,46.8% in male and 55.9%,44.1% in female.Conclusions Genetic variants of T21M of UTS2 are association with different gender essential hypertension in Gansu population.

关 键 词：原发性高血压 单核苷酸多态性 硬骨鱼紧张素Ⅱ基因 

分 类 号：R544.1[医药卫生—心血管疾病]